| Japanese |
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| Title | 糖尿病患者の局所脳血流検査 |
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| Subtitle | 原著 |
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| Authors | 長町茂樹*, 小野真一*, 西川卓志*, 上田正人**, 松尾剛志**, 黒木長充**, 陣之内正史***, 星博昭***, 二見繁美***, 大西隆***, 渡邊克司*** |
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| Authors(kana) | |
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| Organization | *宮崎県立日南病院放射線科, **宮崎県立日南病院内科, ***宮崎医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 2 |
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| Page | 145-150 |
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| Year/Month | 1993/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」N-isopropyl-p-123I-iodoamphetamine (以下IMP)を用いてCT上脳梗塞を認めない高齢糖尿病患者(平均67.9歳)11例と非糖尿病患者(平均67.4歳)12例を対象にSPECT検査を行い, 持続動脈血採血法を用いて局所脳血流量を測定した. 糖尿病群では非糖尿病群と比較して, 前頭葉, 高位前頭葉, 側頭葉, 頭頂葉, 後頭葉, 小脳の各部位においていずれも有意な局所脳血流量の低下が認められた(p<0.01). 高齢糖尿病患者では, CT上脳梗塞を認めなくても, 無症候性の潜在的なびまん性の局所脳血流量の低下があることが確認された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, Diabetes mellitus, Regional cerebral blood flow, Reference sampling method |
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| English |
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| Title | Regional Cerebral Blood Flow in Diabetic Patients |
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| Subtitle | Summary |
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| Authors | Shigeki NAGAMACHI*, Shinnichi ONO*, Takushi NISHIKAWA*, Masato AGETA**, Takeshi MATSUO**, Nagamitsu KUROKI**, Seishi JINNOUCHI***, Hiroaki HOSHI***, Shigemi FUTAMI***, Takashi OHNISHI***, Katsushi WATANABE*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Nichinan Hospital of Miyazaki Prefecture, **Department of Internal Medicine, Nichinan Hospital of Miyazaki Prefecture, ***Department of Radiology, Miyazaki Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 2 |
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| Page | 145-150 |
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| Year/Month | 1993/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | N-isopropyl-p-123I-iodoamphetamine (IMP) was used to quantify the regional cerebral blood flow (r-CBF) in 11 diabetic patients (average age; 67.9 years) and 12 non-diabetic subjects (average age; 67.4 years), none of whom had CVD (Cerebrovascular disease) on CT studies. A reference sampling method by continuous arterial blood sampling was used to quantify r-CBF. There were no significant differences in physiological or laboratory data between diabetic and non-diabetic groups except for fasting plasma glucose and HbA1C levels. The average of r-CBF in each region of cerebrum and cerebellum was significantly lower in diabetic group than that in the control group (p < 0.01). These observations show that r-CBF of diabetic patients is reduced, even in the absence of findings of CVD on a CT study. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, Diabetes mellitus, Regional cerebral blood flow, Reference sampling method |
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