| Japanese |
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| Title | 虚血性心疾患に対する99mTc-PPN1011の診断能の評価 - 201Tlおよび心機能との比較検討 - |
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| Subtitle | 原著 |
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| Authors | 高橋範雄*,***, 玉木長良*, 河本雅秀*, 米倉義晴*, 小野晋司**, 野原隆司**, 神原啓文**, 小西淳二*, 山本和高***, 石井靖*** |
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| Authors(kana) | |
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| Organization | *京都大学医学部核医学科, **京都大学医学部第三内科, ***福井医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 30 |
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| Number | 2 |
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| Page | 123-133 |
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| Year/Month | 1993/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」虚血性心疾患が疑われた24例を対象として, 運動負荷99mTc-PPN1011 SPECTを施行し, 冠動脈病変の検出能および虚血心筋の判定能について201Tl SPECTと比較検討を行った. 症例別の sensitivity は99mTc-PPN1011が100%(21/21), 201Tlは95%(20/21)であった. 病変枝ごとの sensitivity, specificity は99mTc-PPN1011がそれぞれ68%(26/38), 80%(24/30)に対し201Tlはそれぞれ66%(25/38), 77%(23/30)と, 両薬剤はほぼ同等の検出能を示した. また, 安静時像あるいは遅延像での分布の改善の有無も83%(20/24)の症例, および88%(106/120)の区域において所見は一致していた. ファーストパス心RIアンギオグラフィによる心機能との同時解析では左室駆出率と灌流スコアの間に安静時(r=0.70), 運動負荷時(r=0.80)とも高い相関がみられた. また, 心筋局所の灌流スコアと壁運動スコアについても高い一致率がみられた. 本剤は虚血性心疾患の診断, 評価に役立つ優れた薬剤と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Emission computed tomography, 99mTc-PPN1011, Thallium-201, Coronary artery disease, Myocardial perfusion |
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| English |
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| Title | Evaluation of Coronary Artery Disease by 99mTc-PPN1011 : Comparison with 201Tl Imaging and Ventricular Function |
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| Subtitle | Summary |
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| Authors | Norio TAKAHASHI*,***, Nagara TAMAKI*, Masahide KAWAMOTO*, Yoshiharu YONEKURA*, Shinji ONO**, Ryuji NOHARA**, Hirofumi KAMBARA**, Junji KONISHI*, Kazutaka YAMAMOTO***, Yasushi ISHII*** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Third Division, Department of Internal Medicine, Kyoto University Faculty of Medicine, ***Department of Radiology, Fukui Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 30 |
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| Number | 2 |
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| Page | 123-133 |
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| Year/Month | 1993/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | To evaluate clinical value of 99mTc-1,2-bis[bis(2-ethoxyethyl)phosphino]ethane (99mTc-PPN1011) imaging for assessing coronary artery disease (CAD), 99mTc-PPN1011 SPECT imaging at post-exercise and at rest was compared with 201Tl SPECT imaging at post-exercise and 3 hours in 24 patients with CAD. The sensitivities for detecting CAD were 100% (21/21) by 99mTc-PPN1011 SPECT and 95% (20/21) by 201Tl SPECT. The sensitivities for detecting stenosed coronary arteries ( >= 75% stenosis) were similar between 99mTc-PPN1011 (68%) and 201Tl (66%). The similar specificity values were obtained by 99mTc-PPN1011 (80%) and 201Tl (77%). The patterns of abnormality (normal, ischemia and scar) were concordant between 99mTc-PPN1011 and 201Tl images in 20 of the 24 cases (83%) and 106 of the 120 segments (88%). In the simultaneous analysis of cardiac function by first pass radionuclide angiography with 99mTc-PPN1011, there was good correlation between left ventricular ejection fraction and perfusion score at rest (r = 0.70) and exercise (r = 0.80). The degrees of abnormality between perfusion and wall motion were similar in 56 of 66 segments (85%) at rest and 52 of 66 segments (79%) at exercise. We conclude that this agent is promising for the diagnosis and evaluation of coronary artery disease. |
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| Practice | Clinical medicine |
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| Keywords | Emission computed tomography, 99mTc-PPN1011, Thallium-201, Coronary artery disease, Myocardial perfusion |
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