| Japanese |
|---|
| Title | 肥大型心筋症の心筋虚血に対するVerapamilの効果 - 運動負荷201Tl心筋SPECTを用いた評価 - |
|---|
| Subtitle | 短報 |
|---|
| Authors | 谷口洋子*, 杉原洋樹*, 大槻克一*, 馬本郁男*, 中川達哉*, 志賀浩治*, 中村隆志*, 東秋弘*, 河野義雄*, 中川雅夫*, 宮尾賢爾** |
|---|
| Authors(kana) | |
|---|
| Organization | *京都府立医科大学第二内科, **京都第二赤十字病院内科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 30 |
|---|
| Number | 1 |
|---|
| Page | 69-73 |
|---|
| Year/Month | 1993/1 |
|---|
| Article | 報告 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」運動負荷201Tl心筋シンチグラム(EX-Tl)を用いて肥大型心筋症の心筋虚血に対するVerapamilの効果を検討した. EX-Tlにて心筋虚血を認めた肥大型心筋症12例を対象に, 無投薬下でEX-Tlを施行後, Verapamil 240mg/日を経口投与し, 平均8.8週後にEX-Tlを再施行した. 9分割したSPECT画像の各領域における灌流低下の程度を視覚的に4段階に評価し, その総和をDefect Scoreとした. さらにTransient Dilation Index(TDI)を心内膜下虚血の指標として算出した. Defect ScoreはVerapamil投与後12例中10例で改善を認め, Defect Scoreの平均値は5.50から3.03へと有意(P<0.001)に減少した. TDIは, Verapamil投与後12例中10例で改善を認め, 7例が正常値になった. TDIの平均値は1.263から1.090へ有意(P<0.01)に減少した. 以上より, Verapamilは肥大型心筋症の心筋虚血を改善することが示された. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Hypertrophic cardiomyopathy, Exercise 201Tl SPECT, Verapamil, Myocardial ischemia. |
|---|
| English |
|---|
| Title | Effect of Verapamil on Myocardial Ischemia in Patients with Hypertrophic Cardiomyopathy : Evaluation by Exercise 201Tl SPECT |
|---|
| Subtitle | Short Communications |
|---|
| Authors | Yoko TANIGUCHI*, Hiroki SUGIHARA*, Katsuichi OOTSUKI*, Ikuo UMAMOTO*, Tatsuya NAKAGAWA*, Kouji SHIGA*, Takashi NAKAMURA*, Akihiro AZUMA*, Yoshio KOHNO*, Masao NAKAGAWA*, Kenji MIYAO** |
|---|
| Authors(kana) | |
|---|
| Organization | *Second Department of Medicine, Kyoto Prefectural University of Medicine, **Department of Medicine, Kyoto Second Red Cross Hospital |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 30 |
|---|
| Number | 1 |
|---|
| Page | 69-73 |
|---|
| Year/Month | 1993/1 |
|---|
| Article | Report |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary]Effect of verapamil on myocardial ischemia in patients with hypertrophic cardiomyopathy (HCM) was evaluated by exercise stress myocardial 201Tl SPECT (EX-Tl). EX-Tl were performed before and after 8.8 weeks of oral verapamil (240 mg/day) in 12 patients with HCM who showed transient 201Tl perfusion defects under control conditions. 201Tl perfusion defect was visually scored and judged for 4 grades as normal (0), mild defect (1), moderate defect (2), and severe defect (3). Transient Dilation Index (TDI) was calculated as an index of subendocardial ischemia. Improvements of defect score were demonstrated in 10 patients after administration of verapamil. Two patients showed no change of defect score. Mean defect score decreased significantly from 5.50 to 3.03 (p<0.001). Although 11 of 12 patients showed abnormal TDI under control conditions, 10 of them revealed improvements of TDI and 7 of those 10 patients disclosed normal TDI after verapamil. Mean TDI decreased from 1.263 to 1.090 significantly (P<0.01). In conclusion, verapamil may improve myocardial ischemia in patients with HCM. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Hypertrophic cardiomyopathy, Exercise 201Tl SPECT, Verapamil, Myocardial ischemia. |
|---|