Japanese
TitleN-isopropyl-p- [123I] iodoamphetamine (123I-IMP) およびダイナミックSPECTを用いた局所脳血流量画像および局所脳血液分配定数画像の高速計算法の開発
Subtitle原著
Authors伊藤浩*, 飯田秀博*, 村上松太郎*, P. M. BLOOMFIELD*, 三浦修一*, 奥寺利男*, 犬上篤*, 小川敏英*, 畑澤順*, 藤田英明*, 下瀬川恵久*, 菅野巖*, 福田寛**, 上村和夫*
Authors(kana)
Organization*秋田県立脳血管研究センター放射線科, **東北大学抗酸菌病研究所放射線医学部門
Journal核医学
Volume30
Number1
Page13-23
Year/Month1993/1
Article原著
Publisher日本核医学会
Abstract「要旨」123I-IMPおよびダイナミックSPECTを用いたweighted integration methodによる局所脳血流量(rCBF)画像および局所脳血液分配定数画像の高速計算法を開発した. 使用したモデルは2コンパートメントモデルである. 本法によるrCBFは15O標識水(H2 15O)を用いたPETによるrCBFとよい相関(r=0.91(P<0.001), Y=0.88X-1.05)を示しその有用性が示された. また, 本法によるrCBFと123I-IMPダイナミックSPECTでの非線形最小二乗法によるrCBFはよく一致し本法の妥当性が確認された. さらに, 3コンパートメントモデル解析で有意な123I-IMPのretaining rate constant(k3)は認められなかったことから, 123I-IMPの脳内での挙動を解析するモデルとしての2コンパートメントモデルの妥当性が示された. また, 局所脳血液分配定数は脳梗塞巣で低値を示し脳梗塞巣周囲ではrCBFと異なる分布を示したことからrCBFとは独立のtissue viability等を含む情報を示すと考えられた.
Practice臨床医学：一般
Keywords123I-IMP, SPECT, Regional CBF, 2 compartment model, Weighted integration method.
English
TitleA Technique for a Rapid Imaging of Regional CBF and Partition Coefficient Using Dynamic SPECT and N-Isopropyl-p-[123I]Iodoamphetamine (123I-IMP)
SubtitleOriginal Articles
AuthorsHiroshi ITOH*, Hidehiro IIDA*, Matsutaro MURAKAMI*, P. M. BLOOMFIELD*, Syuichi MIURA*, Toshio OKUDERA*, Atsushi INUGAMI*, Toshihide OGAWA*, Jun HATAZAWA*, Hideaki FUJITA*, Eku SHIMOSEGAWA*, Iwao KANNO*, Hiroshi FUKUDA**, Kazuo UEMURA*
Authors(kana)
Organization*Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita, **Department of Radiology and Nuclear Medicine, Research Institute for Cancer and Tuberculosis, Tohoku University
JournalThe Japanese Journal of nuclear medicine
Volume30
Number1
Page13-23
Year/Month1993/1
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]IMP is a flow tracer due to a large first pass extraction fraction and high affinity in the brain, but significant clearance from the brain causes change of distribution when the scan start time is delayed. The purpose of the present study is to develop a new method to rapidly calculate a quantitative CBF image by taking into account for the clearance effects. A dynamic SPECT scan was performed on 5 subjects (4 patients with cerebral infarction and 1 normal volunteer) following slow intravenous infusion of 123I-IMP. The arterial input function was obtained by frequent blood sampling and by measuring an octanol extraction ratio for each sample. Firstly, non-linear least square fitting (NLS) was performed to investigate the tracer kinetics of 123I-IMP. The 3 compartment model analysis yielded negligibly small k3 (retaining rate constant) (0.0056 +- 0.0128 (ml/ml/min)), and consistent k1 (transport rate constant) with those determined by 2 compartment model (2CM) analysis (r=0.96, p<0.001). In addition, k1 was consistent with CBF measured by 15O water PET technique. These observations suggested validity of using 2CM for describing the IMP tracer kinetics. Secondly, a weighted integration (WI) technique has been implemented to calculate rapidly images of CBF and partition coefficient (Vd). The WI technique yielded values of CBF (k1) and Vd (k1/k2). They were confirmed to be consistent with those determined by NLS technique (CBF; r=0.99, p<0.001, Vd; r=0.99, p<0.001), and calculated k1 agreed well with PET CBF (r=0.91, p<0.001). We observed changed Vd in infarcted patients. This supports an importance for calculating of Vd image. Vd image will provide additional clinical information because 123I-IMP binding mechanism may be related to cell viability.
PracticeClinical medicine
Keywords123I-IMP, SPECT, Regional CBF, 2 compartment model, Weighted integration method.

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