| Japanese |
|---|
| Title | 心筋梗塞患者における血中ミオシン軽鎖Iの経時的変動に関する臨床的検討 - 冠動脈内血栓融解術の影響 - |
|---|
| Subtitle | 技術報告 |
|---|
| Authors | 中西昌子*, 才木康彦*, 宇井一世*, 太田圭子*, 野沢浩子*, 川井順一*, 富永悦二*, 山口晴司*, 伊藤秀臣*, 日野恵*, 池窪勝治*, 奥町冨久丸**, 加藤洋**, 吉川純一** |
|---|
| Authors(kana) | |
|---|
| Organization | *神戸市立中央市民病院核医学科, **循環器内科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 29 |
|---|
| Number | 12 |
|---|
| Page | 1479-1488 |
|---|
| Year/Month | 1992/12 |
|---|
| Article | 報告 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」急性心筋梗塞23例(ICT施行14例, 非施行9例)について発症早期から血中Myosin LCIとCKの経時的測定を行い, このうち18例についてはおのおのの最大値と回復期の201Tl心筋シンチグラムから求めたinfarct size index, および左室機能との関係について検討した. ICT施行群の64%(9/14)においてMyosin LCIが複数peakを示し, このうち6例の第一peakはいずれもCKのpeakと一致した. 一方, ICT非施行群では9例中1例のみに複数peakを認めた. Myosin LCIの最大値と201Tl心筋SPECTから求めたinfarct size indexとの間にはCKよりもよい相関(r=0.88, P<0.001)が認められた. 以上より血中Myosin LCIの測定は心筋壊死の評価に有用である. また心筋梗塞発症のごく初期に心筋壊死がおこることが示唆された. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Myosin light chain I, Creatine kinase, Acute myocardial infarction, Intracoronary thrombolysis, Infarct size index. |
|---|
| English |
|---|
| Title | Clinical Study on the Time Courses of Serum Myosin Light Chain I Levels in Patients with Acute Myocardial Infarction : Effect of Intracoronary Thrombolysis on Serum Myosin Light Chain I Levels |
|---|
| Subtitle | Technical Reports |
|---|
| Authors | Masako NAKANISHI*, Yasuhiko SAIKI*, Kazuyo UI*, Keiko OHTA*, Hiroko NOZAWA*, Junichi KAWAI*, Etsuji TOMINAGA*, Haruji YAMAGUCHI*, Hidetomi ITO*, Megumu HINO*, Katsuji IKEKUBO*, Fukumaru OKUMACHI**, Hiroshi KATO**, Junichi YOSHIKAWA** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Nuclear Medicine, **Department of Cardiology, Kobe City General Hospital |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 29 |
|---|
| Number | 12 |
|---|
| Page | 1479-1488 |
|---|
| Year/Month | 1992/12 |
|---|
| Article | Report |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary]Changes of serum myosin light chain I (Myosin LCI) concentrations and CK activities were serially measured in 23 patients with acute myocardial infarction. Intracoronary thrombolysis was performed in 14 patients (ICT group) while the remaining 9 patients were treated in the conventional manner (non ICT group). The relationships between the maximum levels of serum Myosin LCI or CK and a myocardial infarct size index or left ventricular function were evaluated in 18 patients. The myocardial infarct size index was determined by 201Tl myocardial scintigrams performed in the chronic phase. Multiple peaks of Myosin LCI were observed in 64% (9/14) of the ICT group and the first peak in 6 of these patients appeared Much earlier in the same time as CK peak than in the non-ICT group, while multiple peaks were seen only in one case in the non-ICT group. The infarct size index by 201Tl myocardial SPECT correlated with maximum Myosin LCI levels (r=0.88, p<0.001, n=10) and CK activities (r=0.67, p<0.05, n=10). These results indicate that the measurement of serum Myosin LCI is very useful for estimating the extent of myocardial damage and suggest that myocardial degeneration occurs at a very early phase of myocardial infarction. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Myosin light chain I, Creatine kinase, Acute myocardial infarction, Intracoronary thrombolysis, Infarct size index. |
|---|