| Japanese |
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| Title | MR Na画像による脳組織のfastおよびslow componentの定量的解析 |
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| Subtitle | 原著 |
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| Authors | 平井宏和*, 山崎克人*, 喜伝名斎**, 河野通雄* |
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| Organization | *神戸大学医学部放射線医学教室, **附属病院中央検査部 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 12 |
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| Page | 1447-1454 |
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| Year/Month | 1992/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」Na溶液に大分子を加えたときのT2短縮効果を, ポリビニルアルコール粉末を用いて画像化した. 0.05%(8.6mEq)から1%(171mEq)までの, 6種の濃度のNa phantomを用いてNa画像を撮像し, Na濃度-信号強度標準曲線を作成した. Na濃度と信号強度の間には比例関係がみられた. 次に15〜50mEqの範囲で6種のNa phantomを作成, 3人の正常ボランティアの頭の周囲に配置し, 後頭葉皮質下および大脳基底核部のNa濃度の定量的解析を試みた. t検定1%(P<0.01)にて, 後頭葉皮質下と大脳基底核部の間で総Naおよびslow componentに有意な差が認められた. また脳腫瘍(髄膜腫)では, fast componentの著しい上昇がとらえられた. Naのfast component量は, 細胞の状態あるいは種類によって異なると考えられ, この成分の定量的解析は脳組織の機能的な情報を得る手段として有用であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | MRI, Na image, in vivo. |
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| English |
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| Title | Quantitative Analysis of Sodium Fast and Slow component in In Vivo Human Brain Tissue Using MR Na Image |
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| Subtitle | Original Articles |
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| Authors | Hirokazu HIRAI*, Katsuhito YAMASAKI*, Hitoshi KIDENA**, Michio KONO* |
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| Authors(kana) | |
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| Organization | *Deparment of Radiology, Kobe University School of Medicine, **Department of Central Laboratory, Kobe University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 12 |
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| Page | 1447-1454 |
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| Year/Month | 1992/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]In vivo sodium concentrations in the normal brain tissue and a tumorous tissue were analyzed using MR Na image. The nuclear magnetic resonance enabled us to devide the signal from sodium in the living tissue into 2 parts based on the differences of T2 value. Those are fast component having the T2 value of less than 5 msec and slow component of 15-40 msec. We investigated the effect of macromolecules on T2 value of sodium image using polyvinylalcohol (PVA) powder. MR Na image was taken with the parameters of TR/TD, 110 ms/1.9 ms (FID image) and TR/TE, 110 ms/20 ms (SE image). Saline solution showed high intensity on both FID image and SE image. Saline solution added PVA (PVA phantom) also showed high intensity on FID image, whereas the signal intensity of PVA phantom in SE image extinguished. To know the relation between the signal intensity and sodium concentration, sodium concentration-signal intensity curve was obtained using phantoms with various sodium concentrations (0.05 - 1.0%). This curve showed a direct proportion between sodium concentration and signal intensity on Na image. We measured further the sodium concentrations of the human brain tissue. Sodium phantoms were arranged around the heads and the MR Na images of the normal brains from 3 volunteers and a patient with a brain tumor (meningioma) were taken. The sodium concentrations of occipital lobe, basal ganglia and the tumorous tissue were calculated using the sodium concentration-signal intensity curve obtained from the phantoms arranged around the heads. Two tailed t-test shows significant differences (p<0.01) in total sodium and slow component between occipital lobe and basal ganglia. Further more high concentration of fast component in tumorous tissue was observed. As fast component reflects the intracellular condition, present experiments suggest that measurement of fast component may be useful for obtaining the functional information of the brain tissue. |
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| Practice | Clinical medicine |
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| Keywords | MRI, Na image, in vivo. |
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