| Japanese |
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| Title | 陳旧性心筋梗塞例における99mTc-methoxy-isobutyl-isonitrile (MIBI) による心電図同期心筋SPECTの有用性とその限界 |
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| Subtitle | 原著 |
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| Authors | 岡山憲一*, 倉田千弘*, 俵原敬*, 田口貴久*, 青島重幸*, 小林明*, 山崎昇*, 川合宏彰**, 金子昌生** |
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| Authors(kana) | |
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| Organization | *浜松医科大学第三内科, **放射線科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 11 |
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| Page | 1331-1339 |
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| Year/Month | 1992/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」新しい心筋血流イメージング製剤である99mTc-methoxy-isobutyl-isonitrile(MIBI)を用いた心電図同期心筋SPECT(ECG-gated SPECT)の有用性について, 心筋梗塞20例を対象に検討した. 安静時に99mTc-MIBI(740MBq)を投与し1時間後からECG-gated SPECTを収集した. 拡張末期(ED)と収縮末期(ES)の各左室心筋像を39領域に分割し, 各領域の取り込み(EDc, ESc)とその相対値(%EDc, %ESc)を求めた. さらに局所壁運動の指標として, 各領域におけるEDからESへのカウント数増加率(%ΔC)およびカウント数増加分をその症例のEDc最大値で割った値(%ΔCn)を算出した. ECG-gated SPECTにより左室心筋は明瞭に描出され, %EDcと%EScは心エコーや左室造影から得られた局所壁運動所見と良好な相関を示した. しかし%ΔCは壁運動と相関せず, %ΔCnは壁運動所見と有意な相関を見たものの, %EDcや%EScとの相関より弱かった. すなわちECG-gated SPECTによる描出は良好であったが, EDからESへのカウント数の変化のみに基づく壁運動の定量評価には限界があると考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-MIBI, Regional wall motion, ECG-gated SPECT, Myocardial infarction. |
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| English |
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| Title | Usefulness and Limitations of ECG-Gated Myocardial Single-Photon Emission Computed Tomography with 99mTc-Methoxy-Isobutyl-Isonitrile (MIBI) in Patients with Prior Myocardial Infarction |
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| Subtitle | Original Articles |
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| Authors | Kenichi OKAYAMA*, Chinori KURATA*, Kei TAWARAHARA*, Takahisa TAGUCHI*, Shigeyuki AOSHIMA*, Akira KOBAYASHI*, Noboru YAMAZAKI*, Hiroaki KAWAI**, Masao KANEKO** |
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| Authors(kana) | |
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| Organization | *Third Department of Internal Medicine, **Department of Radiology, Hamamatsu University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 11 |
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| Page | 1331-1339 |
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| Year/Month | 1992/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]To evaluate the relationship between regional wall motion and 99mTc-methoxy-isobutyl-isonitrile (MIBI) uptake, ECG-gated single-photon emission computed tomography (SPECT) with 99mTc-MIBI was performed in 20 patients with prior myocardial infarction. The left ventricular images at end-diastole (ED) and end-systole (ES) were divided into 39 segments, respectively. Based on circumferential profile analysis, relative uptake (%EDc, %ESc), percent count increase (%ΔC), and normalized percent count increase (%ΔCn) were analyzed in each segment and compared with regional wall motion indices assessed by echocardiography and left ventriculography. ECG-gated SPECT with 99mTc-MIBI provided high contrast tomograms of the left ventricular myocardium. %EDc and %ESc showed good correlations with regional wall motion indices. %ΔC and %ΔCn, however, showed lower correlations compared with %EDc and %ESc. In conclusion, high-quality left ventricular images were obtained with 99mTc-MIBI ECG-gated SPECT, but quantitative analysis based on only percent count increase (%ΔC) have limitations for evaluation of regional wall motion. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-MIBI, Regional wall motion, ECG-gated SPECT, Myocardial infarction. |
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