| Japanese |
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| Title | 放射線治療用核種の生体投与における三次元吸収線量分布の計算アルゴリズム |
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| Subtitle | 原著 |
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| Authors | 内田勲*, 山田康彦**, 小山田日吉丸**, 野村悦司** |
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| Organization | *癌研究会附属病院放射線管理部, **アイソトープ部 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 11 |
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| Page | 1299-1306 |
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| Year/Month | 1992/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」RI標識モノクローナル抗体を含めた放射性医薬品の投与による放射線治療において, 腫瘍ならびに関連臓器の三次元吸収線量分布をそれらの大きさ, 形状および放射能の不均等分布に依存せずに計算できるアルゴリズムを確立した. このアルゴリズムによる三次元吸収線量分布は, 組織中におけるβ線および光子のdose point kernelを用いて, あらかじめ単位累積放射能を含む単位ボクセルについての吸収線量分布を三次元マトリックスで求め, これと三次元マトリックスで与えられた生体内の累積放射能分布との重畳積分により求められる. 本アルゴリズムによる計算結果の正当性ならびに計算精度の高さは, MIRDの甲状腺数学ファントムを用いて, 32P, 90Y, 131Iなど5種類の治療用核種について行ったコンピュータシミュレーションによって確認された. また, 本アルゴリズムは他の計算アルゴリズムに比して著しく計算時間を短縮できる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Internal dosimetry, Three-dimensional dose distribution, Nonuniform activity distribution, Dose point kernel, Radioimmunotherapy. |
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| English |
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| Title | Calculation Algorithm of Three-Dimensional Absorbed Dose Distribution due to In Vivo Administration of Nuclides for Radiotherapy |
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| Subtitle | Original Articles |
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| Authors | Isao UCHIDA*, Yasuhiko YAMADA**, Hiyoshimaru OYAMADA**, Etsuji NOMURA** |
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| Authors(kana) | |
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| Organization | *Department of Radiation Protection, **Department of Nuclear Medicine, Cancer Institute Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 11 |
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| Page | 1299-1306 |
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| Year/Month | 1992/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]In the in vivo administration of radionuclides for radiotherapy including radioimmunotherapy, an algorithm is proposed for the purpose of calculating three-dimensional absorbed dose distributions of tumors and adjacent tissues, and neighboring organs. The absorbed dose distribution due to the algorithm is given by convolution of the three-dimensional dose matrix for a unit cubic voxel containing unit cumulated activity, with the three-dimensional matrix of the cumulated activity distribution given by the same voxel size above. The dose calculation algorithm does not depend upon the source size, the source shape, and the nonuniform and irregular activity distribution, In addition, it can exceedingly decrease computation time compared to other calculation algorithms. Computer simulations were performed using the MIRD thyroid phantom for 32P, 90Y, 131I, 186Re, and 188Re that appear promising for radioimmunotherapy, and their results verified the validity of the proposed calculation algorithm and high accuracy of the calculations. |
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| Practice | Clinical medicine |
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| Keywords | Internal dosimetry, Three-dimensional dose distribution, Nonuniform activity distribution, Dose point kernel, Radioimmunotherapy. |
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