| Japanese |
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| Title | 99mTc-ECDの基礎的検討 |
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| Subtitle | 技術報告 |
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| Authors | 三村浩朗*, 小野志磨人*, 柳元真一*, 友光達志*, 森田浩一*, 西村布紀子*, 村中明*, 永井清久*, 大塚信昭*, 福永仁夫* |
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| Organization | *川崎医科大学附属病院核医学診療部 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 10 |
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| Page | 1227-1236 |
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| Year/Month | 1992/10 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」脳血流シンチグラフィ用製剤として新しく開発された99mTc-ECDについてin vitroにおける基礎的検討を行い, すでに広く臨床応用されている99mTc-HM-PAOと比較した. 99mTc-HM-PAOは, 時間の経過のみならず, 生理食塩水やDiamoxの添加により放射化学純度が低下するため, 標識後早期に, しかもDiamoxなどの薬剤との混和を避けて投与する必要がある. これに対し, 99mTc-ECDの放射化学純度は, 標識後30分から180分まで94〜96%に保たれており, Diamoxまたは生理食塩水の添加直後もほぼ安定であった. このため, 生理食塩水により血管確保された経路からの投与や, Diamoxとの混和が可能と思われた. 99mTc-ECDの血中代謝には, 血球成分の関与が大きいことが示唆されたが, ヘモグロビン濃度に依存するのか否かは不明であった. またウサギ血を用いた代謝速度の検討から, 血中エステラーゼ活性に種属差が存在することが示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-ethyl cysteinate dimer, Cerebral perfusion, SPECT, Radiochemical purity, Extraction rate. |
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| English |
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| Title | A Fundamental Study of 99mTc-Ethyl Cysteinate Dimer (99mTc-ECD) |
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| Subtitle | Technical Reports |
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| Authors | Hiroaki MIMURA, Shimato ONO, Shinichi YANAGIMOTO, Tatsushi TOMOMITSU, Fukiko NISHIMURA, Akira MURANAKA, Koichi MORITA, Kiyohisa NAGAI, Nobuaki OTSUKA, Masao FUKUNAGA |
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| Authors(kana) | |
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| Organization | Department of Nuclear Medicine, Kawasaki Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 10 |
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| Page | 1227-1236 |
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| Year/Month | 1992/10 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]In vitro fundamental studies of 99mTc-ethyl cysteinate dimer (99mTc-ECD), a newly developed radiopharmaceutical for cerebral perfusion scintigraphy, were performed, and were compared with those of 99mTc-HM-PAO, which has been widely applied to clinical use. 99mTc-HM-PAO should not only be injected soon after reconstitution, but also be avoided mixture with saline or drugs such as Diamox, because of its radiochemical purity decreases with the passage of time and the addition of saline and Diamox. On the other hand, the radiochemical purity of 99mTc-ECD reached a constant level of 94-96% at 30 to 180 min after reconstitution, and it remained stable against the addition of saline and Diamox. Therefore, it was suggested that 99mTc-ECD could be injected from an already saline-infused venousline or mixed with Diamox. However, early injection after reconstitution should be avoided, because 99mTc-ECD did not become stable enough to maintain sufficient radiochemical purity until 30min after reconstitution. The present studies are suggested that the red blood cell component is largely related to the metabolism of 99mTc-ECD in blood. Furthermore, from study of the metabolic rate using rabbit blood, it was suggested that a species difference existed in esterase activity in blood. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-ethyl cysteinate dimer, Cerebral perfusion, SPECT, Radiochemical purity, Extraction rate. |
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