| Japanese |
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| Title | N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) およびSPECTによる簡便な局所脳血流量測定法の開発 |
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| Subtitle | 原著 |
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| Authors | 伊藤浩*, 飯田秀博*, 村上松太郎*, P.M.BLOOMFIELD*, 三浦修一*, 奥寺利男*, 犬上篤*, 小川敏英*, 畑澤順*, 藤田英明*, 下瀬川恵久*, 菅野巖*, 福田寛**, 上村和夫* |
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| Authors(kana) | |
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| Organization | *秋田県立脳血管研究センター放射線科, **東北大学抗酸菌病研究所放射線医学部門 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 10 |
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| Page | 1193-1200 |
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| Year/Month | 1992/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」123I-IMP SPECTによる簡便な局所脳血流量(rCBF)の測定法を開発した. 本法で必要なデータは2回のSPECT scanと1回の採血のみである. 123I-IMPの脳からの洗い出しを考慮したモデル(2コンパートメントモデル:influx;k1, outflux;k2)に基づき, 123I-IMP SPECTのearly scan, delayed scanのカウント比とk2のテーブルを作成しこれよりk1すなわちrCBFを求めた. この際, 入力関数はあらかじめ用意した標準入力関数を1回採血データにより較正したものを用いた. 本法によるrCBFとPETによるrCBFとの比較を行い, 本法の妥当性が示され, 特にearly scan, delayed scanの時刻の組み合わせを40, 180分としたときにPETによるrCBFとの間に最もよい相関(r=0.86)が得られた. また, 脳血液分配定数は, X線CT上の正常域と梗塞域との間で有意に異なり, tissue viabilityを示しうると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, SPECT, 2 compartment model, regional CBF. |
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| English |
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| Title | A Method for Measurement of Regional Cerebral Blood Flow Using N-Isopropyl-p-[123I]Iodoamphetamine (123I-IMP) SPECT ; Two Scans with One Point Blood Sampling Technique |
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| Subtitle | Original Articles |
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| Authors | Hiroshi ITOH*, Hidehiro IIDA*, Matsutaro MURAKAMI*, P.M.BLOOMFIELD*, Syuichi MIURA*, Toshio OKUDERA*, Atsushi INUGAMI*, Toshihide OGAWA*, Jun HATAZAWA*, Hideaki FUJITA*, Eku SHIMOSEGAWA*, Iwao KANNO*, Hiroshi FUKUDA**, Kazuo UEMURA* |
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| Authors(kana) | |
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| Organization | *Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita, **Department of Radiology and Nuclear Medicine, Research Institute for Cancer and Tuberculosis, Tohoku University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 10 |
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| Page | 1193-1200 |
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| Year/Month | 1992/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]We have developed a new method to quantitate regional cerebral blood flow (CBF) using 123I-IMP and SPECT. This technique requires two SPECT scans and one blood sampling. Based on the 2 compartment model (influx; k1 and outflux; k2), a table between k2 and ratio of 1st scan counts/ 2nd scan counts was calculated, and a table look up procedure yielded a unique pair of k1 (CBF) and distribution volume(Vd=k1/k2) for each region of interest (ROI). The arterial input function was obtained by one point blood sampling to calibrate the standard input function, which has been obtained from the previous study on 12 subjects. This method was applied to 5 subjects including 1 healthy volunteer and 4 patients with cerebral infarction, and the regional CBF results were compared with those measured by H215O PET technique. Optimized scan time combination was 40, 180 min which provided the best correlation with H215O-CBF. The Vd values obtained in infarcted regions were significantly smaller than those in normal regions, suggesting the importance of measuring Vd for each ROI. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, SPECT, 2 compartment model, regional CBF. |
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