| Japanese |
|---|
| Title | 新しい心筋イメージング剤99mTc-PPN1011の第I相臨床試験 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 久保敦司*, 中村佳代子*, 橋本順*, 三宮敏和*, 岩永史郎**, 橋本省三*, 佐々木康人*** |
|---|
| Authors(kana) | |
|---|
| Organization | *慶應義塾大学医学部放射線科, **内科, ***東京大学医学部放射線科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 29 |
|---|
| Number | 10 |
|---|
| Page | 1165-1176 |
|---|
| Year/Month | 1992/10 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」健常ボランティアを対象とし, 新しい心筋血流イメージング剤99mTc-PPN1011の安全性および体内動態について検討した. 自他覚症状, 身体所見および臨床検査値には, いずれも本剤に起因すると思われる異常な所見は認められず, その安全性には特に問題はないと考えられた. 本剤静注後, 血中からのクリアランスは速やかで, 心筋への摂取は5分後で投与量の平均1.8%と高い値を示し, 3時間後でも1.0%が保持されていた. 肝臓および肺への取り込みもみられたが, 心筋に比べて急速に消失した. 静注後4時間までに投与量の4.7〜24.0%が尿中に排泄され, また, 肝・胆道系からの排泄もみられた. SPECTおよびプラナーともバックグラウンドの少ない明瞭な心筋像が得られ, 心筋イメージング剤としての安全性と有効性が示唆された. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Myocardial perfusion, 99mTc-PPN1011, Biodistribution. |
|---|
| English |
|---|
| Title | Phase I Clinical Trial of a New Myocardial Imaging Agent, 99mTc-PPN1011 |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Atsushi KUBO*, Kayoko NAKAMURA*, Jun HASHIMOTO*, Toshikazu SAMMIYA*, Shiro IWANAGA**, Shozo HASHIMOTO*, Yasuhito SASAKI*** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiology, School of Medicine, Keio University, **Department of Internal Medicine, School of Medicine, Keio University, ***Department of Radiology, Faculty of Medicine, University of Tokyo |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 29 |
|---|
| Number | 10 |
|---|
| Page | 1165-1176 |
|---|
| Year/Month | 1992/10 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary]A new myocardial imaging agent, 99mTc-1,2-bis[bis(2-ethoxyethyl)phosphino]ethane (99mTc-PPN1011) was administered to healthy male volunteers to evaluate its safety and kinetics. No significant drug-related events were observed. After intravenous injection, blood clearance was rapid. Prompt heart uptake (1.8% of the injected dose after 5 minutes) was followed by relatively slow wash-out (1.0% remained after 3 hours). Liver and lung uptake was observed but the clearance was more rapid than in the heart. 4.7-24.0% of the injected 99mTc-PPN1011 was excreted into urine until 4 hours after injection. 99mTc-PPN1011 also seemed to be excreted through hepato-biliary system. Excellent and low-background myocardial images were obtained using either SPECT or planar imaging. We conclude that 99mTc-PPN1011 could be useful for myocardial perfusion imaging. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Myocardial perfusion, 99mTc-PPN1011, Biodistribution. |
|---|