| Japanese |
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| Title | 新しい前立腺特異抗原 (PSA) 測定用キットの基礎的・臨床的検討 |
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| Subtitle | 技術報告 |
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| Authors | 秋山昭人*, 栃本真人*, 伊藤貴章*, 辻野進*, 相沢卓*, 並木一典*, 三木誠* |
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| Organization | *東京医科大学泌尿器科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 9 |
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| Page | 1151-1158 |
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| Year/Month | 1992/9 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」ヨーロッパで開発・汎用されている血清PSA(Prostate Specific Antigen:前立腺特異抗原)測定用キット(ボールエルザPSA:CISD)の日本人における有用性を検討した. 前立腺癌35例, 前立腺肥大症56例, 健常者18例について測定した. 同時に栄研PSA, 同PAPによる測定も行い比較検討した. 測定感度の検討や各種再現性試験, 添加回収試験, 希釈試験などによる基礎的検討の結果は満足できるものであった. 健常男性の平均+2SD値は2.57ng/mlであった. また, 栄研PSAとの間には高い相関性が認められたが, ボールエルザキットの測定値は栄研キットの約2.4倍高い値となった. 各キット間における標準血清や希釈液の違いが大きな要因と考えられた. この点に関して, より詳細な検討が望まれた. 癌と肥大症を中心とする良性疾患との鑑別においてはcut off値を10.0ng/ml付近に設定したときに感度, 特異度ともに最も良好な成績が得られた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Prostate-specific antigen, Tumor marker, Prostate cancer |
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| English |
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| Title | Basic and Clinical Evaluation of the New Kit for Detection of Serum Prostate Specific Antigen (PSA) |
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| Authors | Akihito AKIYAMA, Masato TOCHIMOTO, Takaaki ITO, Susumu TSUJINO, Taku AIZAWA, Kazunori NAMIKI, Makoto MIKI |
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| Authors(kana) | |
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| Organization | Department of Urology, Tokyo Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 9 |
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| Page | 1151-1158 |
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| Year/Month | 1992/9 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]BALL-ELSA PSA is a monoclonal radioimmunometric assay kit for detection of serum prostate specific antigen (PSA) developed and generally used in Europe. Basic and clinical study of the kit was performed for evaluation of it's utility in Japanese patients. The sera from 56 patients with benign prostatic hyperplasia (BPH), 35 patients with prostate cancer (PCA) and 18 normal males were examined. Other kits such as EIKEN PSA and EIKEN PAP (prostatic acid phosphatase) were also evaluated in same sera. The results of the range in the measurement, within-assay error, between-assay error, dilution test, recovery test and others were well satisfied. In our clinical study, mean+2SD of serum PSA values in normal males was 2.57 ng/ml. Serum PSA values determined by the two RIA kits, BALL-ELSA and EIKEN, showed a good correlation (r=0.9909), but the BALL-ELSA PSA kit yielded values about 2.4 times higher than the EIKEN PSA kit on the same sample. We think that the difference might be largely due to differences in assigned PSA calibrators and diluents between the assay kits. Further investigations and discussions were expected on this point. In our study, the most suitable cut-off level for distinguishing PCA from BPH in BALL-ELSA PSA kit was 10.0 ng/ml. |
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| Practice | Clinical medicine |
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| Keywords | Prostate-specific antigen, Tumor marker, Prostate cancer. |
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