| Japanese |
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| Title | 胸部腫瘍における99mTc-HMPAOシンチグラフィの臨床的検討 |
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| Subtitle | 技術報告 |
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| Authors | 菅一能*, 河村光俊*, 西垣内一哉*, 米城秀*, 藤田岳史*, 大野良貴*, 松本常男*, 中西敬*, 宇津見博基**, 山田典将** |
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| Authors(kana) | |
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| Organization | *山口大学医学部放射線科, **附属病院放射線部 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 9 |
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| Page | 1143-1149 |
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| Year/Month | 1992/9 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-HMPAOシンチグラフィを胸部悪性腫瘍11例15病変に施行しプラナー像では陽性率は比較的低いがSPECT像では高い腫瘍集積性が確認された. SPECTによる腫瘍部の健常肺に対する集積比は平均1.26であった. 一方, 99mTc-HMPAOは気管支肺炎にも集積し, さらに放射線照射肺や放射線肺線維症, 無気肺部や化学療法を繰り返し受けた患者の肺野に集積増加を認め, 腫瘍以外に非特異的あるいはsubclinicalな肺障害を反映して集積する可能性が示唆された. 「I. はじめに」99mTc-hexamethylpropylene amineoxime(以下99mTc-HMPAO)は中性, 脂溶性の脳血流シンチ製剤であるが, 最近, 脳以外の臓器や腫瘍の血流評価に応用される可能性が示唆されている. われわれも家兎VX-2腫瘍による基礎的検討から腫瘍血流を反映する新しい腫瘍イメージング製剤となり得ることを報告した. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-HMPAO, Tumor, SPECT, 201TlCl, Pneumonia. |
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| English |
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| Title | Clinical Assessment of 99mTc-HMPAO Scintigraphy in Thoracic Tumors |
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| Subtitle | |
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| Authors | Kazuyoshi SUGA*, Mitsutoshi KAWAMURA*, Kazuya NISHIGAUCHI*, Shigeru YONESHIRO*, Takeshi FUJITA*, Yoshitaka OHNO*, Tsuneo MATSUMOTO*, Takashi NAKANISHI*, Hiromoto UTSUMI**, Norimasa YAMADA** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Yamaguchi University School of Medicine, **Department of Radiology, Yamaguchi University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 9 |
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| Page | 1143-1149 |
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| Year/Month | 1992/9 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]99mTc-hexamethylpropylene amineoxime (99mTc-HMPAO) scintigraphy was performed in 15 malignant tumors in 11 patients and a patient with bronchopneumonia. A high 99mTc-HMPAO affinity for the tumors was observed on SPECT, however, the mean tumor/contralateral normal lung ratios of 99mTc-HMPAO activity (1.26) was lower than that of 201Tl-chloride (2.29). 99mTc-HMPAO uptake was seen not only in the tumors but also in the bronchopneumonia, atelectasis, and irradiated lung (containing radiation fibrosis). Moreover, a diffuse uptake in the lung was seen in a patient received repeated chemotherapy. Therefore, it is emphasized that there is a non-specific 99mTc-HMPAO uptake in those various pulmonary conditions. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-HMPAO, Tumor, SPECT, 201TlCl, Pneumonia. |
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