| Japanese |
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| Title | 18FDG-PETの脳死例への臨床応用 |
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| Subtitle | 短報 |
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| Authors | 百瀬敏光*, 西川潤一*, 渡辺俊明*, 大嶽達*, 佐々木康人*, 佐々木勝**, 三井香児** |
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| Authors(kana) | |
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| Organization | *東京大学医学部放射線医学教室, **救急部 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 9 |
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| Page | 1139-1142 |
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| Year/Month | 1992/9 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」臨床的に脳死が強く疑われた3症例に対し, 18FDG静注によるポジトロンCTを施行し脳グルコース代謝の測定を試みた. 3症例のうち, 1例は頭部外傷, 2例はクモ膜下出血例である. ポジトロンCT測定時, 全例とも深昏睡, 自発呼吸なく, 頭蓋内圧は著明に上昇し, 平均動脈圧にほぼ等しい状態であった. 18FDG投与直後より1フレーム60秒で19フレームのダイナミックスキャンを撮像し, その後, 10分間のスタティックスキャンを18FDG投与40分後より開始した. 3例全例とも, ダイナミックスキャン, スタティックスキャンいずれにおいても, 頭蓋内の18FDGの明らかな集積は認められなかった. この所見は, いずれの症例においても, 血中グルコースを利用した脳内グルコース代謝がほとんど行われていないことを示しており, 18FDG-PETが脳死のグルコース代謝を把握する上で重要な情報を提供するものと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Brain death, Positron emission tomography, Glucose metabolism, 18F-2-fluoro-2-deoxy-D-glucose. |
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| English |
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| Title | Clinical Application of 18F-FDG-PET to the Patients with Brain Death |
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| Subtitle | |
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| Authors | Toshimitsu MOMOSE*, Junichi NISHIKAWA*, Toshiaki WATANABE*, Tohru OHTAKE*, Yasuhito SASAKI*, Masaru SASAKI**, Kohji MII** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Department of ICU, Faculty of Medicine, University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 9 |
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| Page | 1139-1142 |
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| Year/Month | 1992/9 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]In order to evaluate glucose metabolism in brain death, 18F-FDG-PET scans were performed in three patients with clinically highly suspected brain death. One case was caused by head trauma and other two cases were by subarachnoid hemorrhage. All of them were in deep coma without spontaneous breathing, whose intracranial pressure was remarkably elevated up to the level of mean arterial pressure. Nineteen frames of dynamic scan were started soon after intravenous injection of 18F-FDG for one minute per frame, followed by 10 minutes of static scan which started 40 minutes after the injection. Both in dynamic and static scan, no significant intracranial accumulation of 18F-FDG was seen in all of three cases. This finding can be interpreted as the evidence that there is no significant glucose utilization from blood in the brain. This is the first report of clinical application of 18F-FD-PET to brain death. Our results support the clinical diagnosis of brain death and 18F-FDG-PET can be of value for the assessment of glucose metabolism in patients with suspected brain death. |
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| Practice | Clinical medicine |
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| Keywords | Brain death, Positron emission tomography, Glucose metabolism, 18F-2-fluoro-2-deoxy-D-glucose. |
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