| Japanese |
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| Title | 131I-MIBGによる内照射療法を試みたSipple症候群の1例 |
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| Subtitle | 症例報告 |
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| Authors | 古澤光浩*, 下村修*, 冨口静二*, 廣田嘉久*, 高橋睦正*, 山内穣滋**, 岩岡大輔**, 佐藤辰男** |
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| Organization | *熊本大学医学部放射線科, **第三内科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 9 |
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| Page | 1133-1138 |
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| Year/Month | 1992/9 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」褐色細胞腫と甲状腺髄様癌の合併した, いわゆるSipple症候群で, 肺および肝に転移をきたした40歳女性の症例における原発巣を摘出した後転移巣に対し, 131I-MIBG 3.7GBqによる治療を行った. 投与後のシンチグラフィでは肺および肝の転移巣に131I-MIBGの著明な集積を認めた. 投与後1か月の間はCT, MRIなどの画像上は, 腫瘍の大きさに変化は認められなかった. 投与直後, 血中および尿中カテコールアミンは高値を示したが次第に低下していった. これは腫瘍の組織崩壊によりカテコールアミンの放出がおこったものと考えられた. 「I. はじめに」131I-MIBG(metaiodobenzylguanidine)は, 褐色細胞腫, 神経芽細胞腫などの神経外胚葉に由来する腫瘍の局在診断に有用なことはよく知られている. |
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| Practice | 臨床医学：一般 |
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| Keywords | 131I-MIBG, Sipple syndrome, Catecholamine. |
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| English |
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| Title | Radionuclide Therapy of Sipple Syndrome Using Iodine-131 Metaiodobenzylguanidine |
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| Authors | Mitsuhiro FURUSAWA*, Osamu SHIMOMURA*, Seiji TOMIGUCHI*, Yoshihisa HIROTA*, Mutsumasa TAKAHASHI*, Jyoji YAMAUCHI**, Daisuke IWAOKA**, Tatsuo SATOH** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Third Department of Internal Medicine, Kumamoto University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 9 |
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| Page | 1133-1138 |
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| Year/Month | 1992/9 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]A 40-year-old female who had lung and liver metastases from malignant pheochromocytoma was treated with 3.7 GBq 131I-MIBG (metaiodobenzylguanidine). After the treatment, 131I-MIBG showed increased uptake in the metastatic lesions of the lung and liver. The size of tumor was no significant change on CT and MRI, but the intensity of liver metastases decreased gradually on MRI. Prior to the treatment, the levels of adrenaline and noradrenaline were high. One to three days after treatment, the level of these laboratory data further increased, but they gradually decreased in 1 to 3 months. These changes may be due to necrosis of tumor tissue. |
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| Practice | Clinical medicine |
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| Keywords | 131I-MIBG, Sipple syndrome, Catecholamine. |
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