| Japanese |
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| Title | 炭酸水素ナトリウムの呼気中CO2, 血中CO2, HCO3-, PHおよび脳血流に及ぼす影響について |
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| Subtitle | 原著 |
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| Authors | 駒谷昭夫*, 安久津徹*, 吉田道彦*, 山口昂一*, 瀬尾弘志** |
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| Organization | *山形大学医学部放射線科, **脳神経外科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 9 |
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| Page | 1107-1112 |
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| Year/Month | 1992/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」脳血流の予備能を評価する方法には, 炭酸ガス吸入法, およびダイヤモックスや炭酸水素ナトリウムの負荷試験等がある. 炭酸水素ナトリウムを負荷した時の呼気CO2や動脈血中CO2, HCO3-および脳血流の変化を調べ, 脳血管反応性を定量的に評価するための留意点について検討した. その結果, 炭酸水素ナトリウム負荷により, 動脈血中のHCO3-, PH値はほぼ同程度に増加したが, PaCO2や終末呼気CO2濃度および脳血流の増加の程度は大きくばらついた. 脳血流の増加率はHCO3-やPH値の増加率と有意の正相関が認められたが, PaCO2や終末呼気CO2濃度の増加率とは相関しなかった. また, 安静時にみられたPaCO2と終末呼気CO2濃度の良好な相関関係は, 炭酸水素ナトリウム負荷時には相関しなくなった. 炭酸水素ナトリウム負荷による脳血流予備能の評価は, PaCO2だけでなくHCO3-やPHと対比することにより定量的に行える可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Cerebral blood flow, Sodium bicarbonate, 133Xe inhalation SPECT, Cerebral blood flow reactivity. |
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| English |
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| Title | Effects of Sodium Bicarbonate on the End-tidal CO2, PaCO2, HCO3-, PH and Cerebral Blood Flow |
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| Subtitle | |
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| Authors | Akio KOMATANI*, Tooru AKUTSU*, Michihiko YOSHIDA*, Koichi YAMAGUCHI*, Hiroshi SEO** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Surgical Neurology, Yamagata University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 9 |
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| Page | 1107-1112 |
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| Year/Month | 1992/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]To estimate the quantitative reactivity of cerebral blood flow (CBF), the effects of sodium bicarbonate on the end-tidal CO2, arterial PaCO2, HCO3-, PH and CBF were examined. The CBF was measured by 133Xe inhalation method with ring type SPECT (HEADTOME). Activation study with sodium bicarbonate administration was performed after 30 minute of resting study, and the reactivity of each parameters was investigated. The arterial HCO3- and PH increased with similar reactivity, but PaCO2, end-tidal CO2 and CBF in the non-injured hemisphere changed with irregular reactivity. The excellent correlation between PaCO2 and end-tidal CO2 was vanished by the administration of sodium bicarbonate. The reactivity of CBF did not correlate with reactivity of PaCO2 and end-tidal CO2, but correlated with arterial HCO3- and PH. Thus the measurement of arterial HCO3- and PH may be indispensable to estimate the CBF reactivity with the administration of sodium bicarbonate. |
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| Practice | Clinical medicine |
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| Keywords | Cerebral blood flow, Sodium bicarbonate, 133Xe inhalation SPECT, Cerebral blood flow reactivity. |
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