| Japanese |
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| Title | ポジトロンCTによる13N-アンモニアの肺における動態解析 - 喫煙による影響 - |
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| Subtitle | 原著 |
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| Authors | 加賀谷秋彦*, 福田寛**, 吉田勝哉*, 遠藤真広**, 氷見寿治*, 庭山博行*, 増田善昭*, 稲垣義明*, 鈴木和年**, 須原哲也**, 山崎統四郎**, 舘野之男** |
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| Authors(kana) | |
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| Organization | *千葉大学医学部第三内科, **放射線医学総合研究所臨床研究部 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 9 |
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| Page | 1099-1106 |
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| Year/Month | 1992/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」13N-アンモニア投与後の肺の放射能の動態解析を行い, 喫煙による影響を検討した. 健常18例を対象として, それぞれ非喫煙者, 喫煙中止者, 喫煙者に分類した. また, 肺の腹側, 外側, 背側の部位の違いについても検討した. ダイナミック法による肺の時間放射能曲線は, 一峰性のピークとそれに引き続く下降した曲線が得られ, 片対数プロットによりクリアランスの異なった2相性のパターンが認められた. このデータより, クリアランスの早い相と遅い相をそれぞれfast component, slow componentと定義した. そしてslow componentの大きさを示すretention fraction(RF)と各相の半減時間を求めた(t 1/2 fast component, t 1/2 slow component). その結果, 非喫煙者や喫煙中止者に比較して, 喫煙者でRFの増加とt 1/2 slow componentの延長が認められたが, 肺の各部位による差異は認められなかった. すなわち, 長期喫煙が肺の13N-アンモニアの動態に影響を与えており, その変化は禁煙により可逆的であることが示された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 13N-ammonia, Positron emission tomography, Pulmonary kinetics, Cigarette smoking. |
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| English |
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| Title | Pulmonary Kinetics of 13N-Ammonia in Smoking Subjects - A Quantitative Study Using Dynamic PET - |
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| Authors | Akihiko KAGAYA*, Hiroshi FUKUDA**, Katsuya YOSHIDA*, Masahiro ENDO**, Toshiharu HIMI*, Hiroyuki NIWAYAMA*, Yoshiaki MASUDA*, Yoshiaki INAGAKI*, Kazutoshi SUZUKI**, Tetsuya SUHARA**, Toshiro YAMASAKI**, Yukio TATENO** |
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| Authors(kana) | |
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| Organization | *Third Department of Internal Medicine, Chiba University School of Medicine, **Department of Clinical Research, National Institute of Radiological Sciences |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 9 |
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| Page | 1099-1106 |
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| Year/Month | 1992/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]To evaluate the effect of smoking on nonrespiratory function in the lung, a dynamic PET with 13NH3 in the lung was performed in 18 normal volunteers without lung disease nor congestion (9 non-smokers, 4 exsmokers, 5 smokers). After intravenous bolus injection of 13NH3, twenty serial 5.5-second scans followed by six 30-second scans were performed. Regions of interests were assigned on the ventral, lateral and dorsal part of the right lung and time-activity curves were generated through 26 images. The activity curve demonstrated a biexponential clearance from the lung with fast and slow component. The retention fraction (RF), fractional size of the slow component, was calculated, and the half-times (t 1/2) of both components were also evaluated. A significant increase of RF and prolongation of t 1/2 of slow component were observed in smokers compared to non-smokers and exsmokers. However, no significant difference of RF nor t 1/2 of both components was observed between non-smokers and exsmokers. These results suggest that long term smoking may modify the pulmonary kinetics of 13NH3, but the change is reversible after cessation of smoking for one year or longer. |
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| Practice | Clinical medicine |
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| Keywords | 13N-ammonia, Positron emission tomography, Pulmonary kinetics, Cigarette smoking. |
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