| Japanese |
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| Title | アデノシン負荷201Tl心筋SPECTによる虚血性心疾患の評価 |
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| Subtitle | 原著 |
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| Authors | 竹石恭知*, 千葉純哉*, 阿部真也*, 池田こずえ*, 殿岡一郎*, 駒谷昭夫**, 高橋和栄***, 中川義人****, 白石正****, 友池仁暢* |
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| Authors(kana) | |
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| Organization | *山形大学医学部第一内科, **放射線科, ***附属病院放射線部, ****附属病院薬剤部 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 9 |
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| Page | 1061-1067 |
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| Year/Month | 1992/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」虚血性心疾患を疑い, アデノシン負荷201Tl心筋SPECTを施行した連続55例を対象とした. アデノシンは0.14mg/kg/minを6分間持続静注し, 201Tlは静注開始3分を経過した時点で投与した. アデノシン静注終了5分後と3時間後に心筋SPECT像を撮像した. 得られた短軸および長軸断層像から欠損の有無を視覚的に判定した. アデノシン投与により脈拍は上昇, 血圧は下降し, rate pressure productはわずかに増加した (9314±2377 vs. 10360±2148, p<0.001). 胸痛13例(24%), 頭痛7例(13%), ST低下17例(31%), II度房室ブロック11例(20%)を認めたが, いずれの副作用も軽度かつ一過性で, アデノシン投与中止により速やかに消失した. 冠動脈造影を施行した39例における器質的冠動脈疾患の診断率は, sensitivity 100%(31/31), specificity 88%(7/8)と良好であった. アデノシン負荷201Tl心筋SPECTは虚血性心疾患患者に安全に施行でき, その診断に有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Adenosine, Thallium-201, Ischemic heart disease. |
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| English |
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| Title | Thallium-201 Myocardial Perfusion Imaging during Adenosine-Induced Coronary Vasodilation in Patients with Ischemic Heart Disease |
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| Authors | Yasuchika TAKEISHI*, Junya CHIBA*, Shinya ABE*, Kozue IKEDA*, Ichiro TONOOKA*, Akio KOMATANI**, Kazuei TAKAHASHI***, Yoshito NAKAGAWA****, Tadashi SHIRAISHI****, Hitonobu TOMOIKE* |
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| Authors(kana) | |
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| Organization | *First Department of Internal Medicine, **Department of Radiology, Yamagata University School of Medicine, ***Division of Radiology, ****Department of Pharmacy, Yamagata University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 9 |
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| Page | 1061-1067 |
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| Year/Month | 1992/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]201Tl myocardial perfusion imaging during adenosine infusion was performed in consecutive 55 patients with suspected coronary artery disease. Adenosine was infused intravenously at a rate of 0.14m/kg/min for 6 minutes and a dose of 111 MBq of 201Tl was administered in a separate vein at the end of third minute of infusion. Myocardial SPECT imaging was begun 5 minutes and 3 hours after the end of adenosine infusion. For evaluating the presence of perfusion defects, 2 short axis images at the basal and apical levels and a vertical long axis image at the mid left ventricle were used. The regions with decreased 201Tl uptake were assessed semi-quantitatively. Adenosine infusion caused a slight reduction in systolic blood pressure and an increase in heart rate. The rate pressure products increased slightly (9314+-2377 vs. 10360+-2148, p<0.001). Chest pain (24%) and headache (13%) were the frequent side effects. The second-degree atrioventricular block was developed in 11 of 55 (20%) patients. All symptoms and hemodynamic changes were well tolerated and disappeared within 1or 2 minutes after discontinuing adenosine infusion. The sensitivity and specificity for the detection of patients with coronary artery disease were 100% (31/31) and 88% (7/8), respectively. 201Tl myocardial imaging during adenosine infusion was considered to be safe and useful for evaluating the patients with ischemic heart disease. |
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| Practice | Clinical medicine |
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| Keywords | Adenosine, Thallium-201, Ischemic heart disease. |
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