Japanese
Title子宮悪性腫瘍に対するAngiotensin II併用動注療法施行時の腫瘍血流分布の81mKrを用いた核医学的評価
Subtitle原著
Authors住幸治*, 尾崎裕*, 雨宮謙*, 京極伸介*, 白形彰宏*, 玉本文彦*, 片山仁*, 宇津野博**, 久保田武美**
Authors(kana)
Organization*順天堂浦安病院放射線科, **婦人科
Journal核医学
Volume29
Number8
Page1005-1011
Year/Month1992/8
Article原著
Publisher日本核医学会
Abstract「要旨」子宮悪性腫瘍に対する動注療法におけるカテーテルの至適位置およびAngiotensin IIを用いた昇圧化学療法の有用性の評価を81mKr持続注入による血流分布測定により薬剤の腫瘍への到達性を推定することで試みた. 腫瘍への81mKrのカウントは, 超選択的子宮動脈よりの注入で最も多く, 内腸骨動脈よりの注入時の約3.8倍であった. また, Angiotensin II注入による昇圧化学療法も有効で81mKrのカウントは, 注入前の約1.7倍に増加していた. Angiotensin II注入による血流増加は注入後180秒以内で著しくその後は低下していた. 以上の所見より子宮癌に対する動注としては, 超選択的な子宮動脈よりの注入が最も有効と思われた. しかし, 超選択的に子宮動脈内にカテーテル挿入が困難な場合や広範進展例および術後再発例では, 昇圧化学療法も試みられるべきである.
Practice臨床医学：一般
Keywords81mKr scintigraphy, Angiotensin II, Gynecologic malignancy.
English
Title81mKr Scintigraphic Evaluation of Hemodynamics in Gynecologic Malignancies under Condition of Angiotensin II-Induced Hypertension
SubtitleOriginal Articles
AuthorsYukiharu SUMI*, Yutaka OZAKI*, Ken AMEMIYA*, Shinsuke KYOGOKU*, Akihiro SHIRAKATA*, Fumihiko TAMAMOTO*, Hitoshi KATAYAMA*, Hiroshi UTSUNO**, Takeyoshi KUBOTA**
Authors(kana)
Organization*Department of Radiology, **Department of Gynecology, Juntendo Urayasu Hospital
JournalThe Japanese Journal of nuclear medicine
Volume29
Number8
Page1005-1011
Year/Month1992/8
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]Transcatheter arterial infusion chemotherapy is one of the most useful therapeutic procedures for gynecologic malignancies. Recently, several reports have been published about Angiotensin II-induced hypertension chemotherapy and the efficacy of the method, but there have been no reports to evaluate an application for gynecologic malignancies. We evaluate the usefulness of the method for gynecologic malignancies demonstrating the changes of hemodynamics of the tumor using 81mKr scintigraphy. Thirteen patients with pathologically confirmed gynecologic malignancies were evaluated by angiography and continuous infusion of 81mKr via the catheter with and without Angiotensin II. At first, continuous infusion of 81mKr was performed under the superselective catheterization of the uterine artery. The radioactivities in the ROI were counted. Then, withdrawed the catheter from the uterine artery to the internal iliac artery, and again continuously infused 81mKr and counted the radioactivities in the same ROI. Finally, keeping the catheter in the internal iliac artery, Angiotensin II and 81mKr were infused simultaneously. And counted the radioactivities. The radioactivities were highest when the catheter tip was placed in uterine arteries and lowest when the catheter tip was placed in internal iliac arteries. But radioactivities in the ROIs were definitely increased when Angiotensin II was used, even if the catheter tip was keeping in the internal iliac arteries. The optimal catheter position of transcatheter arterial chemotherapy for gynecologic malignancies is at proximal uterine artery. Since Angiotensin II-induced hypertension may increase blood flow of tumors, it seems to have indication for postoperative cases, highly advanced cases and cases with difficulties to perform superselective catheterization. From our experience, we believe chemothrapeutic agents must be administrated via catheter within 3 minutes after infusion of Angiotensin II.
PracticeClinical medicine
Keywords81mKr scintigraphy, Angiotensin II, Gynecologic malignancy.

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