| Japanese |
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| Title | リンパシンチグラフィ用製剤99mTc-レニウムコロイドの有効性と安全性の検討 |
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| Subtitle | 原著 |
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| Authors | 渡辺克司*1, 野井倉武憲*2, 山下佐英*3, 福永仁夫*4, 折田薫三*5, 中野俊一*6, 川名正直*7 |
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| Authors(kana) | |
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| Organization | *1宮崎医科大学放射線科(TCK-17治験総括医師), *2鹿児島大学歯学部歯科放射線科, *3鹿児島大学歯学部第一口腔外科, *4川崎医科大学核医学科, *5岡山大学医学部第一外科, *6大阪府立成人病センターアイソトープ診療科, *7帝京大学医学部附属市原病院放射線科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 8 |
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| Page | 979-990 |
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| Year/Month | 1992/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」リンパ系の異常を疑われた患者(191名, 196回検査)を対象として, リンパシンチグラフィ用薬剤99mTc-レニウムコロイド(TCK-17)の有効性と安全性について多施設による検討を行った. 薬剤投与時に注射局所に疼痛(79.6%), 腫脹(5.1%)が認められ, また, 2例で軽度の発熱が認められた. 症例ごとに安全性を判定した結果, 判定不能であった5例を除き全症例で安全性に問題がないと判定された. 確定診断が得られた症例で正診率を算出した. また, 同時期に施行された他の診断法による判定とも比較した. TCK-17は他の診断法と比較して, 感度は高い診断法であるが, 特異性は低いという結果であった. 有効性を「きわめて有効」, 「有効」, 「やや有効」, 「どちらとも言えない」, 「無効」の5段階に分けて評価した. 有効以上の判定を有効とした場合の有効率は67.3%であった. TCK-17はリンパの状態をよく反映する診断薬であり, 容易にしかも安全に投与でき有用な検査薬と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Lymphoscintigraphy, 99mTc-rhenium colloid, Malignant lymphoma, Malignant tumor, Lymph edema. |
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| English |
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| Title | Phase III Trial of 99mTc-Rhenium Colloid for Lymphoscintigraphy |
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| Subtitle | Original Articles |
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| Authors | Katsushi WATANABE*1, Takenori NOIKURA*2, Sukehide YAMASHITA*3, Masao FUKUNAGA*4, Kunzo ORITA*5, Shunichi NAKANO*6, Masanao KAWANA*7 |
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| Authors(kana) | |
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| Organization | *1Department of Radiology, Miyazaki Medical College, *2Department of Dental Radiology, Kagoshima University Dental School, *3Department of Oral and Maxillofacial Surgery, Kagoshima University Dental School, *4Division of Nuclear Medicine, Kawasaki Medical School, *5First Department of Surgery, Okayama University School of Medicine, *6Department of Nuclear Medicine, The Center for Adult Disease, *7Department of Radiology, Teikyo University Ichihara Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 8 |
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| Page | 979-990 |
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| Year/Month | 1992/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]A multicenter study was carried out on 191 patients (196 examinations) with lymphatic system disorders to evaluate the efficacy and safety of 99mTc-rhenium Colloid, a tracer for lymphoscintigraphy (TCK-17). Local pain and swelling occured at the site of injection in 79.6% and 5.1% of patients, respectively, and 2 patients experienced mild fever. The accuracy was calculated on the basis of the results obtained by other diagnostic methods. Lymphoscintigraphy using TCK-17 was sensitive diagnostic procedures, but low specificity. The efficacy was classified into five grades: "Excellent", "Good", "Moderate", "Equivocal", and "Poor". 67.3% of all examination were evaluated as "Excellent" or "Good". This study revealed TCK-17 was a useful radiopharmaceutical for lymphoscintigraphy because of its safety and effectiveness. |
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| Practice | Clinical medicine |
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| Keywords | Lymphoscintigraphy, 99mTc-rhenium colloid, Malignant lymphoma, Malignant tumor, Lymph edema. |
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