| Japanese |
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| Title | 201Tlと99mTc MIBIの心筋内動態と臓器分布に対するウアバイン投与の影響 - CsIを使用した小型検出器によるラットのin vivo study - |
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| Subtitle | 原著 |
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| Authors | 丹下正一* |
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| Authors(kana) | |
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| Organization | *東京女子医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 8 |
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| Page | 963-970 |
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| Year/Month | 1992/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」ラットを用いて99mTc MIBIと201Tlの心筋内動態の相違について検討した. Na-K ATPase阻害剤であるウアバインの投与早期群(OU15群)と投与120分後の群(OU120群)を設定した(各詳5匹). 両製剤投与後1分と15分での臓器摂取率(%ID/g)を測定し, また小型検出器(ヨウ化セシウム)によるin vivoの心臓における時間放射能曲線を比較した. 201Tlの臓器摂取率はOU15群ではコントロール群(CON群)に比し心筋摂取率の増加(CON群:1.86±0.42, OU15群:10.81±1.90)と洗いだしの増加(1分後:10.81±1.90, 15分後6.61±1.68)を認めた. OU120群では逆に初期摂取率の低下とともに洗いだしの低下(1分後2.12±0.38, 15分後1.70±0.21)がみられた. 201Tlの時間放射能曲線はOU15群では洗いだしが早く, OU120群では著明に遅延していた(CON群:19%, OU15群:22%, OU120群:9%(15分値)). 一方99mTc MIBIの心筋摂取率は, ウアバインによる影響を受けず, 時間放射能曲線も変化しなかった. 以上の結果から, 99mTc MIBIはNa-K ATPaseの影響を受けないのに対し, 201Tlでは心筋内摂取と保持にNa-K ATPase活性が関与していると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | %ID/g, Time activity curve, 201Tl, 99mTc MIBI, Ouabain. |
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| English |
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| Title | Effects of Ouabain on 201Tl and 99mTc MIBI Kinetics in Rat Myocardium - In Vivo Study Using Miniature CsI Detector - |
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| Subtitle | Original Articles |
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| Authors | Shoichi TANGE |
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| Authors(kana) | |
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| Organization | Department of Radiology, Tokyo Women's Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 8 |
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| Page | 963-970 |
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| Year/Month | 1992/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]The aim of this study is to investigate the effect of ouabain (inhibitor of Na-K ATPase) in the myocardial uptake and clearance of 201Tl and 99mTc MIBI using rats. Time activity curves of three groups were measured by CsI miniature detector for 15 min after the administration of each radiopharmaceutical. Groups were divided as follows; 1) control group (CON group), 2) early phase as 15min after the administration of ouabain (OU15 group), and 3) late phase as 120 min after the administration of ouabain (OU120 group). Main organs of rats including myocardium were resected at 1 min and 15min after the administration of 201Tl or 99mTc MIBI under the anesthesia of pento-barbital sodium. The uptake (%ID/g) of 201Tl or 99mTc MIBI was measured by well type scintillation counter. The uptake of 201Tl of OU15 group was significantly higher than CON group (OU15: 10.81+-1.90, CON: 1.86+-0.42) and cleared more rapidly. On the contrary, OU120 group showed lower uptake (1.70+-0.2) and slower clearance than OU15 group. Time activity curve of OU15 group indicated the accelerated washout compared with CON group. However, OU120 group showed significantly the reduced washout (CON group: 19%, OU15 group: 22%, OU120 group: 9%). On the other hand, the uptake and time activity curves of 99mTc MIBI were not influenced by ouabain administration. In conclusion, myocardial uptake and clearance of 99mTc MIBI were not related to Na-K ATPase activity, while those of 201Tl were markedly influenced by Na-K ATPase. |
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| Practice | Clinical medicine |
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| Keywords | %ID/g, Time activity curve, 201Tl, 99mTc MIBI, Ouabain. |
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