| Japanese |
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| Title | 99mTc-ethyl cysteinate dimer (99mTc-ECD) の血中代謝の検討 - in vitroを中心に - |
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| Subtitle | 原著 |
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| Authors | 井上優介*, 百瀬敏光*, 天羽健*, 大嶽達*, 渡辺俊明*, 小坂昇*, 西川潤一*, 佐々木康人* |
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| Organization | *東京大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 8 |
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| Page | 955-962 |
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| Year/Month | 1992/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-ethyl cysteinate dimer(99mTc-ECD)の血中代謝について, in vitroを中心に検討した. 99mTc-ECDを12例の成人から採取した血中で反応させたところ, オクタノール抽出率yは速やかに低下し, 反応時間tとの関係は指数関数y=Ae-kt/1000(A, k:定数)でよく近似された. 血漿中での分解は緩徐であった. k値とヘマトクリット値Htは有意に相関し(k=0.376Ht-3.27, r=0.897, p<0.001), ECD分解酵素が主に赤血球に存在することが示唆された. 血中で反応させて血球中と血漿中のECDの分布を調べたところ, 血漿での分解で説明されるよりも多くのECD分解産物が血漿中に存在していた. 動脈血採血とそのオクタノール抽出から求めた99mTc-ECDの入力関数からは, オクタノール抽出率の急速な低下が関与して, 有効な入力は比較的短時間で行われていると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-ethyl cysteinate dimer(99mTc-ECD), Hydrophilic conversion, In vitro, Input function. |
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| English |
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| Title | Metabolism of 99mTc-Ethyl Cysteinate Dimer (99mTc-ECD) in Blood - Mainly In Vitro |
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| Subtitle | Original Articles |
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| Authors | Yusuke INOUE, Toshimitsu MOMOSE, Ken AMO, Tohru OHTAKE, Toshiaki WATANABE, Noboru KOSAKA, Jun-ichi NISHIKAWA, Yasuhito SASAKI |
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| Authors(kana) | |
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| Organization | Department of Radiology, Faculty of Medicine, University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 8 |
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| Page | 955-962 |
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| Year/Month | 1992/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Metabolism of 99mTc-ethyl cysteinate dimer (99mTc-ECD) in blood was studied mainly in vitro. When 99mTc-ECD was mixed with blood taken from 12 subjects, the octanol extraction ratio of ECD (y) decreased rapidly and the octanol extraction ratio-time profile well fitted a monoexponential curve (y=Ae-kt/1000, A, k: constant, t: time after mixing). The k value and hematocrit (Ht) were significantly correlated (k=0.376Ht-3.27, r=0.897, p<0.001), therefore, it was suggested that the majority of the enzyme which dissolves ECD exists in red blood cells. When ECD was mixed with blood, there were more hydrophilic products of ECD in plasma than those generated by the enzyme in plasma. In vivo input function of 99mTc-ECD was calculated by arterial blood sampling and octanol extraction. The duration of effective input was relatively short, which was attributed to rapid decrease of octanol extraction ratio in vivo. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-ethyl cysteinate dimer(99mTc-ECD), Hydrophilic conversion, In vitro, Input function. |
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