| Japanese |
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| Title | リコンビジェンEPOキットによる血清エリスロポエチン濃度の測定と臨床応用 |
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| Subtitle | 技術報告 |
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| Authors | 正木洋治*, 岡暢之*, 古家寛司*, 大國智司*, 高木千恵子*, 佐藤利昭*, 野津和巳*, 加藤讓* |
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| Organization | *島根医科大学第一内科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 6 |
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| Page | 701-707 |
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| Year/Month | 1992/6 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」血清エリスロポエチン(EPO)のRIAキット(DPC社)の臨床応用について検討した. 本法による健常成人180名の血清EPO濃度は, 18.6±5.6mU/ml(平均値±標準偏差)であり, 性差を認めなかった. 70歳代の高齢者は若年者より高値を示した. 腎機能健常者では, 血清EPO濃度はHt値と負の相関を示した. 慢性腎不全患者の血清EPO値は健常範囲にあり, 貧血の程度に比較して相対的に低値であった. 糖尿病患者, 甲状腺機能低下症患者の血清EPO値は健常人より高値を示した. 急性白血病, 多発性骨髄腫, 骨髄異形成症候群, 再生不良性貧血, 赤芽球癆の血清EPO値は著しい高値を示した. 赤芽球癆におけるステロイドパルス療法に伴う血清EPO濃度の低下は, 貧血の改善や網状赤血球の増加に先行して観察された. したがって血清EPO濃度の測定は貧血の鑑別診断のみでなく, 治療経過の指標としても有用である. |
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| Practice | 臨床医学：一般 |
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| Keywords | Erythropoietin(EPO), RIA, Diagnosis of anemia, Renal function, Pure red cell aplasia. |
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| English |
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| Title | Clinical Use of Serum Erythropoietin Determination by Recombigen EPO RIA Kit |
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| Subtitle | Technical Reports |
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| Authors | Yohji MASAKI, Nobuyuki OKA, Hiroshi FURUYA, Satoshi OHGUNI, Chieko TAKAGI, Toshiaki SATO, Kazumi NOTSU, Yuzuru KATO |
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| Authors(kana) | |
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| Organization | First Division, Department of Medicine, Shimane Medical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 6 |
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| Page | 701-707 |
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| Year/Month | 1992/6 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Serum erythropoietin (EPO) levels were determined by the recombigen EPO RIA kit (DPC) in normal subjects and patients with renal dysfunction, diabetes mellitus, hypothyroidism and a variety of hematological disorders. Mean (+-SD) serum EPO levels were 18.6+-5.6 mU/ml in 180 normal subjects and no sex difference was obtained. Serum EPO levels in older subjects were slightly greater than those in younger subjects. There was a negative correlation between serum EPO levels and Ht values in anemic patients with normal renal function, whereas serum EPO levels were within the normal range in anemic patients with renal disorders, suggesting that serum EPO levels were relatively low in patients with chronic renal failure. Serum EPO levels were rather increased in patients with diabetes mellitus and hypothyroidism. High serum EPO levels were obtained in patients with a variety of hematological disorders such as acute leukemia, multiple myeloma, myelodysplasia syndrome, aplastic anemia and pure red cell aplasia. In a patient with pure red cell aplasia treated with glucocorticoids, serum EPO levels were lowered before anemia was recovered and reticulocytes were increased. These findings indicate that measurement of serum EPO levels are useful for not only differential diagnosis of anemia but also clinical evaluation of the treatment. |
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| Practice | Clinical medicine |
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| Keywords | Erythropoietin(EPO), RIA, Diagnosis of anemia, Renal function, Pure red cell aplasia. |
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