| Japanese |
|---|
| Title | ビタミンA結合蛋白の肺微小血管透過性マーカーとしての有用性の基礎的検討 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 石坂彰敏*, 鈴木幸男*, 金沢実*, 久保敦司**, 川城丈夫* |
|---|
| Authors(kana) | |
|---|
| Organization | *慶應義塾大学医学部内科学教室, **放射線科学教室 |
|---|
| Journal | 核医学 |
|---|
| Volume | 29 |
|---|
| Number | 6 |
|---|
| Page | 679-685 |
|---|
| Year/Month | 1992/6 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」低分子量のビタミンA結合蛋白(VABP)をガンマカメラを用いた肺微小血管透過性検出法として応用するためモルモット実験系を用いて基礎実験を行った. 125I-アルブミン(ALB), 125I-VABP, 99mTc-DTPA(diethylene triamine pentaacetic acid)を静脈内に投与した. エンドトキシン(LPS)投与群(n=7)と生理食塩水投与対照群(n=7)から得られた血液検体と肺組織におけるガンマ線を計測した. 125I-ALBの肺組織と血漿中の計数比(T/P)を求め肺微小血管透過性の指標とした. 肺水分蓄積の指標として肺湿乾重量比(W/D)を算出した. LPS投与により123I-ALBのT/PとW/Dが高値を示し, LPS投与により透過性肺水腫が招来されたと考えた. 125I-VABPのT/Pも高値を示しLPSによる微小血管透過性亢進を125I-VABPを用いて検出できた. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Capillary permeability, Vitamin A binding Protein. |
|---|
| English |
|---|
| Title | Usefulness of Vitamin A Binding Protein as a Marker for Capillary Endothelial Permeability |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Akitoshi ISHIZAKA*, Yukio SUZUKI*, Minoru KANAZAWA*, Atsushi KUBO**, Takeo KAWASHIRO* |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Medicine, **Department of Radiology, School of Medicine, Keio University |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 29 |
|---|
| Number | 6 |
|---|
| Page | 679-685 |
|---|
| Year/Month | 1992/6 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary]We performed a preliminary study to assess the usefulness of Vitamin A binding protein (VABP) as a gamma-camera marker for capillary endothelial permeability. We used a guinea pig model of endotoxin (LPS) induced acute lung injury. We calculated the concentration ratio of either 125I-albumin or 125I-VABP in lung tissue to that in plasma (tissue plasma ratio; T/P) as a parameter of capillary endothelial permeability. 99mTc-diethylene triamine pentaacetic acid (DTPA) was used as a marker for pulmonary interstitial volume. We estimated wet to dry lung weight ratio as a parameter of lung water accumulation (W/D). LPS increased the T/P of 125I-albumin and W/D, suggesting the development of permeability edema. The T/P for 125I-VABP was also increased, indicating that 125I-VABP can be used to detect elevated capillary endothelial permeability. In both groups, LPS and saline, the T/P was higher for 125I-VABP than for 125I-albumin. These data suggest that the pulmonary capillary endothelium is more permeable to VABP than albumin. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Capillary permeability, Vitamin A binding Protein. |
|---|