| Japanese |
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| Title | 脊髄小脳変性症における99mTc-Ethyl Cysteinate Dimer (ECD) による脳血流SPECT : PETによる局所脳血流との比較 |
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| Subtitle | 原著 |
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| Authors | 織内昇*, 渡辺直行*, 舘野円*, 冨吉勝美*, 平野恒夫*, 井上登美夫*, 遠藤啓吾*, 五十嵐均**, 田中真***, 平井俊策***, 佐々木康人**** |
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| Authors(kana) | |
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| Organization | *群馬大学医学部核医学科, **附属病院中央放射線部, ***神経内科, ****東京大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 6 |
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| Page | 659-665 |
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| Year/Month | 1992/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」脊髄小脳変性症(SCD)12例を対象として, 99mTc-ethyl cysteinate dimer(ECD)を用いた脳血流SPECTおよびC15O2ガスを用いたポジトロンCT(PET)による局所脳血流量(rCBF)測定を行い, 両者を比較検討した. 両画像は類似し, 11例では肉眼的にも明らかな小脳における対称性の血流低下を示した. 残りの1例は, 小脳/後頭葉のカウント比をとることにより, X線CTでは萎縮の明らかでない小脳の血流低下が示された. 体重あたりの投与量で補正した脳内14か所の関心領域内のECDカウント(count/pixel/MBq/kg)により, 投与15分後の早期像に対して, 60分後の後期像は, 5.1%の洗い出しを認めた. 洗い出しは一様で, 再分布は認めなかった. ECDカウントとPETによるrCBFは, 相対的な高血流域においても直線性の相関を示した. 回帰式は, ECD早期像がy=0.901x+11.26(r=0.920), ECD後期像がy=0.984x+3.51(r=0.927)で, 後期像の方がPETとよく相関した. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-ECD, SPECT,PET, Spinocerebellar degeneration. |
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| English |
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| Title | Clinical Evaluation of 99mTc Ethyl Cysteinate Dimer SPECT in Patients with Spinocerebellar Degeneration ; Comparison with Cerebral Blood Flow Determined by PET |
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| Subtitle | Original Articles |
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| Authors | Noboru ORIUCHI*, Makoto TANAKA**, Hitoshi IGARASHI***, Naoyuki WATANABE*, Madoka TATENO*, Tomio INOUE*, Katsumi TOMIYOSHI*, Tsuneo HIRANO*, Keigo ENDO*, Shunsaku HIRAI**, Yasuhito SASAKI**** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Neurology, ***Department of Diagnostic Radiology, Gunma University School of Medicine, ****Department of Radiology, Faculty of Medicine, University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 6 |
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| Page | 659-665 |
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| Year/Month | 1992/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Technetium-99m ethyl cysteinate dimer (99mTc-ECD) is regarded as a promising radiopharmaceutical for imaging regional cerebral blood flow (rCBF). We evaluated 99mTc-ECD SPECT comparing with rCBF images obtained by PET in 12 patients with spinocerebellar degeneration (SCD). SPECT images of 99mTc-ECD demonstrated characteristic findings of decreased rCBF in bilateral cerebellar hemisphere and almost identical with PET rCBF images in all patients based on the visual inspection. Semiquantitative analysis by drawing 14 intracranial regions of interest on SPECT and PET images revealed linear correlation between 99mTc-ECD count and rCBF measured by PET even in relatively high rCBF regions. In summary, 99mTc-ECD is a promising tracer for evaluating rCBF in patients with SCD and distribution of it correlates well with rCBF measured by PET. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-ECD, SPECT, PET, Spinocerebellar degeneration. |
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