| Japanese |
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| Title | 腹部大動脈瘤における血小板集積と抗血小板剤の効果に関する検討 - 血小板シンチグラフィを用いて - |
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| Subtitle | 原著 |
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| Authors | 恵谷秀紀*1,*2, 木村和文*3, 井坂吉成*4, 金奉賀*1, 中真砂士*1, 木下直和*2, 額田忠篤*1, 宇治茂*5, 鷲谷文男*5, 松岡利幸*5, 北川一夫*6 |
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| Authors(kana) | |
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| Organization | *1国立大阪南病院循環器科, *2臨床研究部, *3大阪船員保険病院内科, *4国立大阪病院循環器科, *5国立大阪南病院放射線科, *6大阪大学医学部第一内科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 6 |
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| Page | 651-657 |
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| Year/Month | 1992/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」腹部大動脈瘤12例を対象に動脈瘤部位での血栓形成能を評価する目的で111In-血小板, 99mTc-人血清アルブミンによる血小板シンチグラフィを施行し, 血小板集積を定性的ならびに半定量的(Platelet accumulation index;PAI)に解析し, その血小板集積に対する抗血小板剤の効果も検討した. PAIは大動脈瘤部位における血管壁に集積した血小板の放射能と流血中に存在する血小板の放射能の比率として求めた. 腹部大動脈瘤12例中, 視覚判定では11例が陽性であり, 半定量的指標PAIは53.8±34.1%でコントロール群のPAI-8.6±4.4%に比べて有意な上昇を認めた(p<0.01). 陽性11例のうち7例で3週間アスピリン投与後, 再度シンチグラフィを施行したところ, 視覚判定では5例が引き続き陽性, 1例がequivocal, 1例が陰性となった. アスピリン投与後陽性を示した5例中, 2例はアスピリン非投与時に比べてシンチグラム上血小板集積の程度は変化なく, 3例は減少を示した. 7例において半定量的評価ではPAI値は, アスピリン非投与時の52.1±23.9%と比較して, アスピリン投与後21.9±18.6%であり有意な減少を示した(p<0.01). 本法はin vivoの血小板の活性化をより客観的に評価でき, 大動脈瘤症例での血栓形成能と抗血小板剤の効果判定に有用であることが示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Abdominal aortic aneurysm, Platelet scintigraphy, In vivo thrombogenicity, Platelet accumulation index(PAI), Antiplatelet drug. |
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| English |
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| Title | Platelet Accumulation in Abdominal Aortic Aneurysm and the Effect of Antiplatelet Drugs : Assessment by Indium Platelet Scintigraphy |
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| Subtitle | Original Articles |
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| Authors | Hideki ETANI*1,*2, Kazufumi KIMURA*3, Yoshinari ISAKA*4, Bong-Ha KIM*1, Masashi NAKA*1, Naokazu KINOSHITA*2, Tadaatsu NUKADA*1, Shigeru UZI*5, Fumio WASHITANI*5, Toshiyuki MATSUOKA*5, Kazuo KITAGAWA*6 |
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| Authors(kana) | |
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| Organization | *1Department of Cardiovascular Medicine, Osaka-Minami National Hospital, *2Department of Clinical Research, Osaka-Minami National Hospital, *3Department of Internal Medicine, Osaka Seamen's Insurance Hospital, *4Department of Internal Medicine, Osaka National Hospital, *5Department of Radiology, Osaka-Minami National Hospital, *6First Department of Internal Medicine, Osaka University Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 6 |
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| Page | 651-657 |
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| Year/Month | 1992/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]A dual tracer technique using 111In labeled platelets and 99mTc labeled human serum albumin was applied to evaluate the in vivo thrombogenicity in 12 cases with abdominal aortic aneurysm (AAA) and the effect of antiplatelet drug on the thrombogenicity. The magnitude of platelet accumulation at AAA was expressed as the ratio of radioactivity of 111In platelets on the vascular wall to those in the blood pool (PAI; platelet accumulation index). Of the 12 patients with AAA, 11 had positive studies on baseline imaging and 1 had equivocally positive image. The PAI value (Mean+-SD) over the AAA was 53.8+-34.1% as compared to -8.6+-4.4% in the control group (p<0.01). Seven patients with an AAA and positive baseline images were restudied during platelet active drug with 325 mg of aspirin. During treatment with aspirin, of 7 patients, 5 had positive images, of which 3 were decreased and others unchanged compared to baseline studies, 1 equivocally positive one and one negative one. The PAI value during treatment (21.9+-18.6%) was significantly decreased compared to those in baseline study (52.1+-23.9%). Our results suggest that the method used for platelet imaging in the present study may be useful for studying the in vivo thrombogenicity and the effect of platelet active drugs in AAA. |
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| Practice | Clinical medicine |
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| Keywords | Abdominal aortic aneurysm, Platelet scintigraphy, In vivo thrombogenicity, Platelet accumulation index(PAI), Antiplatelet drug. |
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