| Japanese |
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| Title | 1H-NMRスペクトロスコピーによる合成FDG液中立体異性体の分析 |
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| Subtitle | 技術報告 |
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| Authors | 今関恵子*, 恵良田知樹**, 岡田淳一*, 吉川京燦*, 宇野公一*, 有水昇*, 吉沢卓***, 能勢忠男*** |
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| Authors(kana) | |
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| Organization | *千葉大学医学部放射線医学教室, **筑波大学物理工学系, ***筑波大学臨床医学系脳神経外科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 5 |
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| Page | 639-642 |
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| Year/Month | 1992/5 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」アセチルハイポフルオライト法で合成した18F-2-fluoro-2-deoxy-D-glucose(FDG)溶液中に含まれる18F-2-fluoro-2-deoxy-D-mannose(FDM)の存在比を1H-NMRスペクトロスコピーを用いて分析した. FDG中のFDMは, 約4%であった. FDGではβ型がα型より多く存在した. FDMではα型がやや多かった. FDG液中の一位のCの1Hの信号により存在比を求めることは十分に可能であった. 当施設の合成FDG中の4%のFDMの混入量は, 腫瘍および心臓のPET検査上ほとんど問題にならないと考えた. 「I. はじめに」2-Fluoro-2-Deoxy-D-glucose(FDG)は, 糖の同族体として, 18F標識糖がPET検査に多用されている. 18F標識FDGの合成の際は, 副産物として, 立体異性体2-Fluoro-2-Deoxy-D-Mannose(FDM)の混入が指摘されている. |
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| Practice | 臨床医学：一般 |
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| Keywords | Stereoisomer, FDG, FDM, 1H-NMR spectroscopy, PET study. |
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| English |
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| Title | Analysis of Stereoisomers Involved Products of Synthesized 18F-2-Deoxy-2-Fluoro-D-glucose by 1H-NMR Spectroscopy |
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| Subtitle | Technical Report |
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| Authors | Keiko IMAZEKI*, Tomoki ERATA**, Junichi OKADA*, Kyousan YOSHIKAWA*, Kimiichi UNO*, Noboru ARIMIZU*, Takashi YOSHIZAWA***, Tadao NOSE*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Chiba University School of Medicine, **Institute of Applied Physics, University of Tsukuba, ***Department of Neurological Surgery, Institute of Clinical Medicine University of Tsukuba |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 5 |
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| Page | 639-642 |
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| Year/Month | 1992/5 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]18F-2-fluoro-2-deoxy-D-mannose (FDM) is eventually involved in sideproducts of 18F-2-fluoro-D-glucose (FDG) synthesized by the acetylhypofluorite method. We attemped the measurement of existence ratio of FDM and FDG, FDMα and FDMβ, FDGα and FDGβ by 400 MHz 1H-NMR spectroscopy. The ratio of FDM to FDG were 4.0%. The amounts of FDGβ were much larger than those of FDGα. The difference between the amounts of FDMα and FDMβ were not significant. 1H-NMR spectroscopy could be utilized in quantitative analysis of products and byproducts in cyclotron chemicals. The FDM in FDG synthesized in our cyclotron system was not considered to affect a lot of influence in PET study. |
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| Practice | Clinical medicine |
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| Keywords | Stereoisomer, FDG, FDM, 1H-NMR spectroscopy, PET study. |
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