| Japanese |
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| Title | 血清心筋ミオシン軽鎖I流出曲線と201Tl心筋像によるバイパス手術における術中心筋障害の評価 |
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| Subtitle | 原著 |
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| Authors | 田中健*, 相澤忠範*, 加藤和三*, 青木啓一*, 高梨秀一郎*, 古田昭一* |
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| Authors(kana) | |
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| Organization | *心臓血管研究所 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 5 |
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| Page | 591-598 |
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| Year/Month | 1992/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」心電図では術中梗塞が否定されるバイパス手術12例において心筋ミオシン軽鎖(軽鎖)と安静時201Tl心筋像を検討した. 全例において軽鎖は大動脈遮断解除から平均91±29分後に最大値(15.3±7.2ng/ml, T-peak)を示し, 平均1.4±0.9時間の半減期で減少した. 5例では平均6時間後に正常化した. MBは17.6±9.3時間後に最大値(34.6±23.0mU/ml)を示した. 201Tl心筋像は4例で改善を示し, 1例では不変であった. 7例では平均12.7±5.9時間後に2.7±0.6ng/mlまで減少し, この後再上昇し平均3.1±0.9日目に再び最大値(5.6±0.9ng/ml, M-peak)を示した. MBは3.2±1.3時間後に最大値(61.3±19.9mU/ml)を示した. 201Tl心筋像は3例で悪化の疑い, 2例で不変, 2例で改善を示した. T-peakは大動脈遮断中の心筋障害と関連し, 心筋梗塞時の心筋障害とは異なり, 慢性期の心筋壊死と関係が少ないと推定された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Myosin light chain I, 201Tl myocardial images, Perioperative myocardial injury. |
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| English |
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| Title | Estimation of Perioperative Myocardial Infarction in Patients under Aorto-Coronary Bypass Grafts with Plasma Level of Myosin Light Chain I and 201Tl SPECT |
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| Subtitle | Original Articles |
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| Authors | Takeshi TANAKA, Tadanori AIZAWA, Kazuzo KATO, Keiichi AOKI, Shuichiro TAKANASHI, Shoichi FURUTA |
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| Authors(kana) | |
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| Organization | The Cardiovascular Institute |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 5 |
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| Page | 591-598 |
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| Year/Month | 1992/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]After aorto-coronary bypass grafts surgery plasma level of myosin light chain I, determined with monoclonal antibodies to myosin light chain I (LC-I), were studied in 12 patients (pts) without electrocardiographical perioperative myocardial infarction. Rest 201Tl myocardial images were collected before and after surgery. LC-I increased and reached peak levels (15+-7ng/ml) at 91+-29 minutes after the aortic declamp. From peak levels LC-I rapidly decreased with fast half-time disappearance (1.4+-0.9 hours). In 5 pts of 12pts LC-I recovered to normal range and MB reached maximum levels (34+-23 IU/L) at 18+-9 hours after declamp. In 4 pts 201Tl images showed improvement and in one 201Tl images showed no changes. In 7 pts of 12 pts LC-I decreased to minimum levels (2.7+-0.6 ng/ml) at 12+-6 hours and then gradually increased to peak levels (5.6+-0.9 ng/ml) on day 3+-0.9. MB reached maximum level (61+-20 IU/L) at 3.2+-1 hours. In 201Tl images 3 pts showed suspected new lesion, 2 pts showed no changes and 2 pts showed improvement. No correlation was noted between peak LC-I level and duration of aortic declamp. No significant relation was suspected between early LC-I peak and irreversible myocardial cell injury. From close relationship between aortic declamp and appearance of LC-I peak, it was concluded that LC-I, accumulated during aortic clamp, was washed out by aortic declamp. Relation was suspected between early LC-I peak and myocardial injury during myocardial protection. Late LC-I peak may be useful for estimation of perioperative irreversible myocardial injury. |
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| Practice | Clinical medicine |
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| Keywords | Myosin light chain I, 201Tl myocardial images, Perioperative myocardial injury. |
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