| Japanese |
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| Title | 99mTc-DTPAエアロゾル吸入による進行性全身性強皮症に伴う間質性肺炎の診断 |
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| Subtitle | 原著 |
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| Authors | 舘野円*, 中野明彦**, 長谷川昭**, 渡辺直行*, 織内昇*, 井上登美夫*, 遠藤啓吾*, 佐々木康人*** |
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| Organization | *群馬大学医学部核医学科, **第二内科, ***東京大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 5 |
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| Page | 585-590 |
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| Year/Month | 1992/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」間質性肺炎を合併することが多い, 進行性全身性強皮症32例を対象として, 99mTc-DTPAエアロゾルによる肺クリアランス検査を施行した. 胸部CTにて肺野に異常所見を認めない群でも, 99mTc-DTPAエアロゾルの肺からのクリアランス時間は正常群に比して明らかに短縮していた. CTにて間質性陰影を認めた群(21例)と認めない群(11例)の間には, 99mTc-DTPAの肺からのクリアランス時間には有意差なく, 肺拡散能力, 肺活量とも相関関係は認められなかった. 3か月から19か月の間隔でCT, 99mTc-DTPAエアロゾル検査を繰り返し施行した8例のうち, 間質性陰影の出現・悪化に先んじてクリアランス時間の短縮を認めた症例や, CT所見には変化がないがクリアランス時間の改善された症例も見られた. 本法は進行性全身性強皮症患者において, 自覚症状はあるが, 他覚的所見の乏しい時期の肺病変を検出し得る可能性があると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-DTPA, Aerosol inhalation, Progressive Systemic Scleroderma(PSS), Interstitial pneumonia. |
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| English |
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| Title | Pulmonary Clearance of 99mTc-DTPA Aerosol in Patients with Progressive Systemic Scleroderma |
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| Subtitle | Original Articles |
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| Authors | Madoka TATENO*, Akihiko NAKANO**, Akira HASEGAWA**, Naoyuki WATANABE*, Noboru ORIUCHI*, Tomio INOUE*, Keigo ENDO*, Yasuhito SASAKI*** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Second Department of Internal Medicine, Gunma University School of Medicine, ***Department of Radiology, Faculty of Medicine, University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 5 |
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| Page | 585-590 |
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| Year/Month | 1992/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Alveolar epithelial permeability was assessed in 32 patients with progressive systemic scleroderma (PSS), using 99mTc-DTPA aerosol. Immediately after the inhalation of 99mTc-DTPA aerosol for 3 to 6 minutes under normal tidal breathing, lung was imaged sequentially for 30 minutes from the posterior by a gamma camera and exponential fitting was processed on the time activity curve. T1/2 (min) was used as a parameter for the evaluation of permeability of alveolar epithelium. Patients with collagen disease showed shorter T1/2 (T1/2=43.7+-23.8 min) than the normal volunteers (T1/2=76.8+-8.7 min). No significant difference was observed between patients with or without interstitial changes on the chest CT. Significant correlation was not observed between T1/2 and %VC or %DLco. In 8 cases, studies were repeated in the interval of 3 to 19 months. Improvement of T1/2 was seen in 4 cases, independent of CT findings. These results suggest that 99mTc-DTPA aerosol clearance study provides information independent from other lung examinations, and may be useful for the assessment of lung interstitial changes in patients with PSS. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-DTPA, Aerosol inhalation, Progressive Systemic Scleroderma(PSS), Interstitial pneumonia. |
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