| Japanese |
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| Title | 家兎の放射線照射肺における123I-IMP肺シンチグラフィの検討 |
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| Subtitle | 原著 |
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| Authors | 菅一能*, 有吉功*, 西垣内一哉*, 中西敬*, 宇津見博基**, 山田典将** |
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| Organization | *山口大学医学部放射線科, **附属病院放射線部 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 4 |
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| Page | 443-451 |
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| Year/Month | 1992/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」片肺へ50Gy放射線照射した11家兎に照射後3-17週の間に123I-IMP肺シンチグラフィを施行したところ, 123I-IMP静注1時間後の遅延像で照射側肺に異常集積を認めた. 時間放射能曲線から123I-IMPの肺内動態を検討すると, 非照射側肺では早期に集積した123I-IMPが速やかに洗い出されるのに対し, 照射側肺では早期には非照射側肺に比し集積が低いが, その後の洗い出しが遅延し, 時間経過とともに両者の集積が逆転し, 照射側肺が相対的に高集積となり, 異常集積を示す様子が示された. このうち6兎で99mTc-MAAによる肺動脈血流の評価も行い, 照射側肺の血流低下を認めたが, 123I-IMPの静注後早期の分布との間には相違を認めた. この期間中に123I-IMP肺シンチグラフィを施行した11兎の, いずれの胸部X線写真でも異常陰影を認めず, このうち6兎の病理組織像は, 対側非照射肺に比して変化はきわめて軽微であった. これらの家兎で123I-IMPの肺内動態の異常を検出し得たことから, 123I-IMP肺シンチグラフィが放射線による早期の肺障害を把握するのに有用である可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-isopropyl-p-123I-iodoamphetamine, Lung, Radiation, Pulmonary perfusion. |
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| English |
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| Title | Experimental Study on 123I-IMP Kinetics in Irradiated Lung of Rabbit |
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| Subtitle | Original Article |
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| Authors | Kazuyoshi SUGA*, Isao ARIYOSHI*, Kazuya NISHIGAUCHI*, Takashi NAKANISHI*, Hiromoto UTSUMI**, Norimasa YAMADA** |
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| Authors(kana) | |
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| Organization | *Departmenr of Radiology, Yamaguchi University School of Medicine, **Department of Radiology, Yamaguchi University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 4 |
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| Page | 443-451 |
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| Year/Month | 1992/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Radiation-induced alteration of intra-pulmonary kinetics of 123I-IMP was investigated in 11 rabbits received a 50 Gy dose of radiation to the hemithorax. In all of these rabbits examined during 3-17 weeks following the irradiation, an abnormal accumulation was seen in the irradiated lung on the delayed image obtained 60 minutes after the injection of 123I-IMP. The time-activity curves in the irradiated lung following the injection had shallower downslopes of both the initial fast phase and the following slow phase than those of non-irradiated lung, and finally 123I-IMP uptake of the irradiated lung exceeded that of the normal lung. Chest radiographies all of 11 rabbits showed no abnormal shadow and histological studies in 6 of them revealed a relatively slight change or injury of the irradiated lung during 3-17 weeks. These results indicate that this agent may be useful for detecting and assessing relatively early and slight lung injury induced by irradiation. |
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| Practice | Clinical medicine |
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| Keywords | N-isopropyl-p-123I-iodoamphetamine, Lung, Radiation, Pulmonary perfusion. |
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