| Japanese |
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| Title | N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) と回転型ガンマカメラによる局所脳血流定量法の開発とその評価 - テーブル参照法の理論と精度について - |
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| Subtitle | 短報 |
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| Authors | 撫中正博*, 飯田秀博** |
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| Organization | *産業医科大学脳神経外科, **秋田県立脳血管研究センター放射線科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 3 |
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| Page | 385-389 |
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| Year/Month | 1992/3 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」N-isopropyl-p-[123I]iodoamphetamine(123I-IMP)と回転型ガンマカメラを用いた局所脳血流の新しい定量法を考案した. 従来のmicrosphere modelではなく, 脳からの洗いだしを考慮した2 compartment modelによる解析を行った. すなわち, early scanとdelayed scanにおいて得られた画像のピクセル値に対して, 局所脳血流値(rCBF)と分布容積(Vd)の2つのパラメータをテーブル参照法を用いて, 2元2連連立方程式の解として求め得た. この方法にて, 正常成人2例, 脳梗塞1例の計3例において, 局所脳血流値を求め, 同時に施行したpositron emission tomography(PET)との比較を行った. 本法による各ROIのrCBF値は平均で灰白質40ml/100g/min, 白質27ml/100g/minをとり, PETによるrCBF値に対してr=0.598(p<0.001)と有意の相関があり, 回帰直線はy=0.61x+13.9であった. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-isopropyl-p-[123I]iodoamphetamine, Rotating gamma camera, Positron emission tomography, Look-up table method, Regional cerebral blood flow. |
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| English |
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| Title | New Quantification of Regional Cerebral Blood Flow Measurements by 123I-IMP SPECT with the Rotating Gamma Camera - Theory and Validation of the Look-Up Table Method - |
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| Subtitle | Short Communication |
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| Authors | Masahiro MUNAKA*, Hidehiro IIDA** |
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| Authors(kana) | |
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| Organization | *Department of Neurosurgery, University of Occupational and Environmental Health, **Department of Radiology, Research Institute for Brain and Blood Vessels-Akita |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 3 |
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| Page | 385-389 |
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| Year/Month | 1992/3 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]A new method of quantifying regional cerebral blood flow (rCBF) measurements by N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) SPECT with a rotating gamma camera was designed. By assuming the 2 compartment model of the kinetic for 123I-IMP, two parameters of rCBF and distribution volume (Vd) of 123I-IMP from brom brain tissue to blood were obtained by the look-up table method and were derived from two simultaneous equations of the early and delayed images. The rCBF values of 3 cases (two normal adults and one brain infarct patient) were calculated by this method and were compared with the values of positron emission tomography (PET) measured at the same time. The average rCBF values in gray and white matter by this method were 40 ml/100 g/min, 27 ml/100 g/min, respectively and correlated significantly to rCBF values by PET (r=0.598 (p<0.001)). |
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| Practice | Clinical medicine |
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| Keywords | N-isopropyl-p-[123I]iodoamphetamine, Rotating gamma camera, Positron emission tomography, Look-up table method, Regional cerebral blood flow. |
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