| Japanese |
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| Title | 133Xeおよび99mTc-phytateを用いた抗癌剤持続動注症例における肝血流動態の評価 |
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| Subtitle | 原著 |
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| Authors | 中村一彦* |
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| Authors(kana) | |
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| Organization | *鳥取大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 3 |
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| Page | 377-383 |
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| Year/Month | 1992/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」肝細胞癌3例, 術後肝細胞癌再発1例, 転移性肝癌16例を対象として, 手術時もしくは経皮的に留置された抗癌剤持続動注用皮下リザーバーより, 133Xe生理食塩液を注入し, 腫瘍部および非腫瘍部における局所肝血流量を測定した. 同時に99mTc-phytateを静注し, 腫瘍部, 非腫瘍部各部位における肝動脈血流・門脈血流成分比を算出した. 133Xeクリアランス法より求めた局所肝血流量は, 腫瘍部, 非腫瘍部ともに抗癌剤持続動注による治療経過に伴って一定の変化を示さなかった. 99mTc-phytateの時間-放射能曲線より得られた肝動脈血流成分比は, これまでの報告と同様に腫瘍部において有意に高かった. また, 腫瘍縮小率と腫瘍部肝動脈血流量との間には有意な負の相関がみられ, 抗癌剤持続動注による縮小率の高かった症例では肝動脈血流の減少がみられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 133Xe, Hepatic hemodynamics, Liver tumor, Implantable drug infusion system. |
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| English |
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| Title | Hepatic Blood Flow in Patients Treated by Continuous Hepatic Artery Infusion Chemotherapy |
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| Subtitle | Original Articles |
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| Authors | Kazuhiko NAKAMURA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Tottori University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 3 |
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| Page | 377-383 |
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| Year/Month | 1992/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Hepatic blood flow in tumor and nontumor regions was studied in four patients with hepatocellular carcinoma and in 16 patients with metastatic liver tumors. The regional hepatic blood flow was measured with the tissue clearance of 133Xe delivered through the implantable drug infusion system. The regional hepatic arterial/portal blood flow ratio was also measured by means of intravenous injection of 99mTc-stannous phytate. Mean hepatic arterial blood flow ratio of tumor regions was higher than that of nontumor regions (81.83+-24.55% vs. 46.64+-20.05%; p<0.01). This result suggests that hepatic arterial blood flow is increased in tumor regions of the liver. In tumor regions, the regional blood flow of the hepatic artery was inversely correlated with the mass reduction rate. In the lesions that showed a higher mass reduction rate by the continuous drug infusion treatment, the endothelial damage of the arterial wall and tumor necrosis seem to decrease blood flow. From this study, measurement of regional hepatic blood flow and hepatic arterial/portal blood flow ratio may be useful to evaluate the effectiveness of treatment for hepatic tumors. |
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| Practice | Clinical medicine |
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| Keywords | 133Xe, Hepatic hemodynamics, Liver tumor, Implantable drug infusion system. |
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