Japanese
Title肝細胞癌の診断における99mTc-PMT後期イメージングの有用性の評価
Subtitle原著
Authors長谷川義尚*, 中野俊一*, 井深啓次郎*, 橋詰輝巳*, 野口敦司*, 春日井博司**, 田中幸子**, 井上敦雄**, 児島淳之介**, 藤田真***, 佐々木洋****, 今岡真義****
Authors(kana)
Organization*大阪府立成人病センター核医学診療科, **内科, ***放射線診断科, ****外科
Journal核医学
Volume29
Number3
Page367-376
Year/Month1992/3
Article原著
Publisher日本核医学会
Abstract「要旨」肝細胞癌およびこれと鑑別を要する各種肝疾患において99mTc-PMT後期イメージングを施行した. 肝細胞癌199例のうち強陽性102例(51.3%)および弱陽性26例(13.1%), 合計128例(64.3%)が陽性所見を呈した. 一方, 肝細胞癌以外の悪性肝腫瘍22例では2例(9.1%)が弱陽性所見を呈したに過ぎなかった. したがって本検査法は肝細胞癌の質的診断法として有用であることを明らかにした. つぎに, 効率的に本検査法を行う目的でこの検査による肝細胞癌の陽性率とイメージング時期, およびコロイド肝シンチグラム所見の関係について, さらに腫瘍の放射能集積判定に影響を及ぼすと考えられる肝臓非腫瘍部, 肝内胆管, 胆嚢および消化管内の残存放射能, および悪性肝腫瘍以外の腫瘍性肝病変の集積像などについて検討した成績を述べた.
Practice臨床医学：一般
KeywordsHepatocellular Carcinoma, 99mTc-PMT, Delayed imaging.
English
TitleEvaluation of 99mTc-PMT Delayed Imaging in Diagnosis of Hepatocellular Carcinoma
SubtitleOriginal Articles
AuthorsYoshihisa HASEGAWA*, Shunichi NAKANO*, Keijirou IBUKA*, Terumi HASHIZUME*, Atsushi NOGUCHI*, Hiroshi KASUGAI**, Sachiko TANAKA**, Atsuo INOUE**, Jyunnosuke KOJIMA**, Makoto FUJITA***, Yo SASAKI****, Shingi IMAOKA****
Authors(kana)
Organization*Department of Nuclear Medicine, **Department of Internal Medicine, ***Department of Radiology, ****Department of Surgery, The Center for Adult Diseases
JournalThe Japanese Journal of nuclear medicine
Volume29
Number3
Page367-376
Year/Month1992/3
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]99mTc-PMT delayed imaging was performed on 199 patients with hepatocellular carcinoma (HCC), and 72 patients with various hepatic diseases, from which HCC should be differentiated. Of the 199 patients with HCC, 128 (64.3%) showed positive results on 99mTc-PMT images. Of these 128, 102 (51.3%) showed increased uptake of radioactivity by the hepatic tumor as compared with the surrounding non-tumorous area of the liver, and 26 (13.1%) showed equal uptake. On the contrary, only 2 (9.1%) of the 22 patients with other malignant hepatic tumors (7 with cholangiocellular carcinoma and 15 with metastatic liver tumors) showed equal uptake of 99mTc-PMT. These findings indicated that 99mTc-PMT delayed imaging was useful for increasing the specificity in diagnosis of HCC. Of the patients with HCC showing increased uptake on 99mTc-PMT images taken 5-hour after the injection of the radioisotope, 26.3%, 69.6%, and 96.0% showed intense 99mTc-PMT uptake by hepatic tumor on 1-hour, 2-hour, and 3-hour images, respectively. These findings indicated that in diagnosing HCC, 5-hour image should be taken only in the patients with a hepatic tumor showing no increased uptake of radioactivity even on 3-hour image. Moreover, the rate of HCC to take up 99mTc-PMT intensely was higher in patients with hepatic tumor showing filling defect on colloid liver image than in those showing no filling defect (p<0.001). The points in the assessment of radioactivity uptake by hepatic tumor on 99mTc-PMT delayed image were as follows: Overlapping of radioactivity excreted into the gall bladder or intestine with the radioactivity of the liver tumors, radioactivity retention in the non-neoplastic portion of the liver, and the radioactivity of the dilated intrahepatic bile duct were noted in 6 (2.6%), 15 (6.5%) and 9 (3.9%), respectively, among the 230 patients with focal space occupying lesions. Further, a patient of giant nodular regenerative hyperplasia showed increased uptake of 99mTc-PMT consistent with the hepatic lesion.
PracticeClinical medicine
KeywordsHepatocellular Carcinoma, 99mTc-PMT, Delayed imaging.

【全文PDF】