| Japanese |
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| Title | 123I-BMIPP (β-methyl iodophenyl pentadecanoic acid) による虚血性心疾患の診断 |
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| Subtitle | 原著 |
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| Authors | 植原敏勇*, 西村恒彦*, 汲田伸一郎*, 下永田剛*, 林田孝平*, 岡尚嗣*, 斉藤克己**, 野々木宏**, 土師一夫** |
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| Organization | *国立循環器病センター放射線診療部, **心臓内科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 3 |
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| Page | 347-359 |
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| Year/Month | 1992/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」側鎖脂肪酸123I-BMIPPを用いて, 急性期・亜急性期の心筋脂肪酸代謝を検討し, かつ201TlClによる心筋灌流, 左室造影による局所壁運動所見と対比した. 対象は心筋梗塞急性期16例(平均発症後6.8±2.6日), 亜急性期8例(平均発症後35±3.0日), 不安定狭心症例7例の計31例である. 心筋梗塞急性期, 亜急性期のいずれにおいても123I-BMIPPは201TlClより大きな欠損像を示し, 特に急性期早期に冠動脈血行再建術が成功した症例で顕著であった. またこれらの症例では123I-BMIPPの欠損像は約1か月後に著明に改善した. 一方, 123I-BMIPPの心筋集積低下は急性期, 亜急性期のいずれにおいても心筋局所壁運動の低下とよく一致したが, 201TlClでは急性期には心筋灌流は良好であるが局所壁運動は低下している, いわゆるstunned, hibernating myocardiumの部位が存在し, 両者は不一致を示した. このようにstunned, hibernating myocardiumの部位では123I-BMIPPは急性期には欠損像を示し亜急性期には改善することから, 本剤は梗塞部位における心筋脂肪酸代謝を画像化できることが示された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-BMIPP, Myocardial imaging, Ischemic heart disease, Stunned myocardium, acute myocardial infarction. |
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| English |
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| Title | Diagnostic Utility of Myocardial Imaging Using 123I-Labeled Beta-Methyl-Iodophenyl Pentadecanoic Acid in Ischemic Heart Disease |
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| Subtitle | Original Articles |
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| Authors | Toshiisa UEHARA*, Tsunehiko NISHIMURA*, Shin-ichiro KUMITA*, Tsuyoshi SHIMONAGATA*, Kohei HAYASHIDA*, Hisashi OKA*, Katsumi SAITO**, Hiroshi NONOGI**, Kazuo HAZE** |
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| Authors(kana) | |
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| Organization | *Department Radiology, **Department of Cardiology, National Cardiorvascular Center |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 3 |
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| Page | 347-359 |
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| Year/Month | 1992/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]We evaluated the myocardial metabolism in the acute and subacute phases of myocardial infarction or unstable angina using 123I-labeled beta-methyl-iodophenyl pentadecanoic acid (BMIPP). We then compared those findings with (1) myocardial perfusion images obtained with 201TlCl and (2) the regional and global left ventricular function determined by left ventriculography. Thirty-one patients were examined, consisting of 16 with acute myocardial infarction (6.8+-2.6 days after onset), 8 with subacute myocardial infarction (35+-3.0 days after onset), and 7 with unstable angina. The BMIPP images showed a larger uptake-defect than 201TlCl images in the patients in the acute or subacute phase of myocardial infarction. This finding was especially remarkable in the acute phase after successful coronary revascularization therapy. Moreover, in such cases, the myocardial BMIPP uptake improved to the same degree as 201TlCl one month later. The decrease in myocardial uptake of BMIPP agreed well with the decrease in regional wall motion in the acute and subacute phases of myocardial infarction. In contrast, the myocardial perfusion of 201TlCl did not always agree with the regional wall motion in stunned or hybernating myocardium, where BMIPP showed an uptake-defect in the acute phase but improved in the subacute phase. Thus, BMIPP is surmised to be able to depict fatty acid metabolism in in vivo myocardial imaging. |
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| Practice | Clinical medicine |
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| Keywords | 123I-BMIPP, Myocardial imaging, Ischemic heart disease, Stunned myocardium, acute myocardial infarction. |
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