| Japanese |
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| Title | N-isopropyl-p- [123I] iodoamphetamine (123I-IMP) と回転型ガンマカメラによる局所脳血流定量法 - 一回動脈採血による簡便法 - |
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| Subtitle | 研究速報 |
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| Authors | 撫中正博*, 飯田秀博**, 村上松太郎** |
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| Authors(kana) | |
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| Organization | *産業医科大学脳神経外科, **秋田県立脳血管研究センター |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 2 |
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| Page | 263-267 |
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| Year/Month | 1992/2 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」123I-IMP SPECTによる局所脳血流定量法の簡便化を考案した. まず, 標準入力関数の作成と標準入力関数を一回採血により較正するための採血時刻の最適化を行った. 標準入力関数は, 健康成人12例の動脈曲線を平均して得た. また, 最適採血時刻は, 持続採血による入力関数と一回採血により較正した標準入力関数との積分値の差が最小値をとる時刻とし, その結果123I-IMP静注後8分となった. また, 脳血流値(rCBF)測定の評価は, 健康成人2例, 脳梗塞1例において, 較正入力関数を用いて得たrCBF値と持続採血による入力関数を用いて得たrCBF値との比較にて行った. 健康成人2例では前者は後者に対して灰白質でそれぞれ平均で+6%, -13%, 白質では+11%, -8%, 72歳の脳梗塞患者では, 灰白質で-23%, 白質では-22%となった. 両者間には相関係数r=0.764(p<0.001)と有意の相関が得られ, 回帰直線はy=0.66x+9.1となった. 以上, 123I-IMP SPECTによる一回採血のみでの定量法を開発した. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, Cerebral blood flow, SPECT, Quantification, Input function. |
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| English |
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| Title | Quantification of Regional Cerebral Blood Flow (rCBF) Measurement with One Point Sampling by 123I-IMP SPECT |
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| Subtitle | Rapid Communication |
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| Authors | Masahiro MUNAKA*, Hidehiro IIDA**, Matsutaro MURAKAMI** |
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| Authors(kana) | |
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| Organization | *Department of Neurosurgery, University of Occupational and Environmental Health, **Department of Radiology, Research Institute for Brain and Blood Vessels-Akita |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 2 |
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| Page | 263-267 |
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| Year/Month | 1992/2 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]A handy method of quantifying regional cerebral blood flow (rCBF) measurement by 123I-IMP SPECT was designed. A standard input function was made and the sampling time to calibrate this standard input function by one point sampling was optimized. An average standard input function was obtained from continuous arterial samplings of 12 healthy adults. The best sampling time was the minimum differential value between the integral calculus value of the standard input function calibrated by one point sampling and the input function by continuous arterial samplings. This time was 8 minutes after an intravenous injection of 123I-IMP and an error was estimated to be +- 4.1%. The rCBF values by this method were evaluated by comparing them with the rCBF values of the input function with continuous arterial samplings in 2 healthy adults and a patient with cerebral infarction. A significant correlation (r=0.764 (p<0.001)) was obtained between both. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, Cerebral blood flow, SPECT, Quantification, Input function. |
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