| Japanese |
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| Title | 急性心筋梗塞後に壁運動が保たれている心筋における抗心筋ミオシン抗体取り込みの検討 |
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| Subtitle | 短報 |
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| Authors | 田中健*, 相澤忠範*, 加藤和三*, 小笠原憲*, 桐谷肇*, 岡本淳* |
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| Authors(kana) | |
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| Organization | *心臓血管研究所 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 2 |
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| Page | 257-261 |
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| Year/Month | 1992/2 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」発作から2-10か月後の心筋梗塞6例を対象として, 壁運動が保たれている心筋における抗心筋ミオシン抗体の取り込みを検討した. Planar像による心筋の抗心筋ミオシン抗体取り込みと肺野の抗心筋ミオシン抗体取り込みの比は平均2.3±0.5であった, 各症例において最も高い抗心筋ミオシン抗体取り込みを認める部位のTl-201摂取率は平均77%(90-63)で, 超音波像による壁運動は1例が良好で5例が低下であった. また矢状面前壁における最も高い抗心筋ミオシン抗体摂取率の平均は83%(100-75)で, またこの部位のTl-201摂取率は平均81%(90-75)で, shortening rateは平均34%(52-25)であった. 再灌流などにより壊死を免れ壁運動が改善した心筋に抗心筋ミオシン抗体取り込みが認められた. 心筋を壊死にいたらせるような虚血により心筋細胞に生じた障害は, 陳旧期でも改善し得ていない可能性が考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | In-111 antimyosin antibody Fab, Reperfusion therapy, Myocardial cell damage. |
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| English |
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| Title | In-111 Antimyosin-Fab Uptake in Contractile Myocardium of Old Myocardial Infarction |
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| Subtitle | Short Communication |
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| Authors | Takeshi TANAKA, Tadanori AIZAWA, Kazuzo KATO, Ken OGASAWARA, Hajime KIRIGAYA, Kiyoshi OKAMOTO |
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| Authors(kana) | |
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| Organization | The Cardiovascular Institute |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 2 |
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| Page | 257-261 |
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| Year/Month | 1992/2 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]As In-111 monoclonal antimyosin antibody (AM) has been thought to bind with human myosin exposed in myocytes irreversiblely damaged by an ischemic event. The AM uptake in contractile myocardium after acute myocardial infarction was studied. AM planar images were obtained 48 hours later after injection of 74 MBq of AM in 6 patients 2-10 months later after acute myocardial infarc-tion. Mean ejection fraction was 66% (75-58). Myocardial AM uptake was definite in com-parison with mediastinum uptake in all 6 patients and mean heart lung ratio was 2.3 +- 0.5. AM SPECT images and Tl-201 SPECT images were obtained with dual mode. Mean Tl-201 uptake at the region of maximal AM uptake was 77% (90-63). Echocardiography showed contractility of the region. Mean maximal AM uptake in the anterior wall region was 83 % (100-75) and mean Tl-201 uptake at the region was 81 % (90-75) and shorten-ing rate of the region was 34% (52-25). The region with AM uptake has been shown to cor-relate with the region salvaged from necrosis by reperfusion. It has been shown that AM was uptaken in contractile myocardium in chronic phase of acute myocardial infarction. It was suspected that myocardium under severe ischemic event may be salvaged by reperfusion therapy and retain contractility in chronic phase, however irrereversible damage, which permit AM uptake, may remain in myocardium. |
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| Practice | Clinical medicine |
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| Keywords | In-111 antimyosin antibody Fab, Reperfusion therapy, Myocardial cell damage. |
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