Japanese
Title虚血性脳血管障害におけるSPECTによる局所脳血液量および血流量 / 血液量測定の臨床的意義
Subtitle原著
Authors仙田宏平*, 丸山邦弘*, 中條正雄*, 横山恵太*
Authors(kana)
Organization*国立名古屋病院放射線科
Journal核医学
Volume29
Number2
Page243-249
Year/Month1992/2
Article原著
Publisher日本核医学会
Abstract「要旨」発症後90日以内の虚血性脳血管障害109症例について, 局所脳血液量(rCBV)および血流量/血液量(rCBF/rCBV)をSPECT像の健常部に対する病巣部の計数比として測定し, その臨床的意義を評価した. rCBV比は, rCBF/rCBV比と有意(p<0.01)な負の相関を認め, RIアンギオグラフィのflip-flop灌流像の程度の異なる2群間ならびに神経学的所見の経過から判別した3病態群間で有意差を示した. rCBF/rCBV比は, rCBF比と有意な正の相関を認め, X線CTの低吸収域像, RIアンギオグラフィの早期灌流像および血管造影の狭窄像の程度の異なる2群間ならびに病態良好群の発症後2週群と3週群間で有意差を示した. これらの成績から, rCBV比は側副灌流を反映し, 本疾患の予後を判定する上で有効であった. また, rCBF/rCBV比は局所酸素摂取率を反映すると考えられ, 脳灌流予備能を推定する上で有用であった.
Practice臨床医学：一般
KeywordsCerebrovascular disease, Regional cerebral blood volume, Regional cerebral blood flow-to-volume, I-123-IMP, Tc-99m-RBC.
English
TitleClinical Significance of Regional Cerebral Blood Volume and Flow-to-Volume Ratio in Ischemic Cerebrovascular Disease Measured by SPECT
SubtitleOriginal Articles
AuthorsKohei SENDA, Kunihiro MARUYAMA, Masao CHUJO, Keita YOKOYAMA
Authors(kana)
OrganizationDepartment of Radiology, National Nagoya Hospital
JournalThe Japanese Journal of nuclear medicine
Volume29
Number2
Page243-249
Year/Month1992/2
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]Regional cerebral blood volume (rCBV) and flow-to-volume ratio (rCBF/rCBV) were evaluated for clinical significance in comparison to rCBF and findings in X-ray CT (XCT) and radionuclide (RNA) and contrast angiography (CAG). A total of 109 cases were studied within 90 days after cerebrovascular ischemic attack. CBV SPECT was per-formed following CBF SPECT with I-123-IMP and RNA with Tc-99m-RBC, and processed for subtraction of I-123 contamination fraction. CBF/CBV image was obtained as the count ratio of CBF to CBV image at the same slice-level. Parametric rCBV and rCBF/rCBV were estimated as the count ratio of the focus to the contralateral normal region of interest. Image findings were scored by visual judgement. Student's t-test was applied for statistical analysis with a significance level of p=0.01. The rCBV-ratio was inversely proportional to rCBF/rCBV-ratio, and was different between the two groups with high and low score on flip-flop perfusion in RNA and among three groups with different postictal neurological course. The ratio was the highest for the group of improved course. The rCBF/rCBV-ratio was possibly correlated to rCBF-ratio, and was different between the two groups with high and low score on low density area in XCT, early perfusion in RNA and arterial stenosis in CAG. In the group of improved course, the ratio was different between the second and the third postictal week's duration. These results, therefore, suggest that rCBV-ratio reflects collateral perfusion, and is valuable for assessing postictal prognosis in cerebrovascular disease, and that rCBF/rCBV-ratio may reflect regional oygen extraction fraction, and is valuable for speculating cerebral perfusion reserve.
PracticeClinical medicine
KeywordsCerebrovascular disease, Regional cerebral blood volume, Regional cerebral blood flow-to-volume, I-123-IMP, Tc-99m-RBC.

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