| Japanese |
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| Title | 99mTc-DTPA-galactosyl-human serum albuminのコンパートメントモデル解析 |
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| Subtitle | 原著 |
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| Authors | 河相吉*, 小島通真*, 田中敬正* |
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| Organization | *関西医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 2 |
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| Page | 203-211 |
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| Year/Month | 1992/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTcガラクトシル人血清アルブミンジエチレントリアミン五酢酸(99mTc-GSA)は, 肝実質細胞のアシアロ糖タンパク受容体結合性肝シンチグラフィ製剤である. 健常者3例および肝硬変患者11例に1mg/185MBq(5mCi)の99mTc-GSAを投与し, 60分間の心肝の時間放射能曲線を得た. 体内動態について, 1)肝外血液, 2)肝内血液, 3)受容体, 4)間質液, 5)尿の5コンパートメントを設定した. 心肝曲線の曲線回帰式を求め, その外挿値をもとに血液中99mTc-GSA量と肝血液容量を算定した. 受容体結合にはMichaelis-Menten型飽和モデルをあてはめ, これより成立する連立微分方程式を数値解析した. その結果, 健常者での肝血流量は1,651±131ml/min, リガンド最大除去量は0.547±0.069mg/minであり, 肝硬変例ではともに有意な低下を示した. 本法は肝血流量と受容体量を分離評価できる新しい肝機能検査法であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-galactosyl-human serum albumin, Compartment model, Hepatic blood flow, Asialoglycoprotein receptor, Liver cirrhosis. |
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| English |
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| Title | A Compartment Model of Tc-99m-DTPA-Galactosyl-Human Serum Albumin for Evaluating Liver Function |
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| Subtitle | Original Articles |
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| Authors | Sang Kil Ha-KAWA, Michimasa KOJIMA, Yoshimasa TANAKA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Kansai Medical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 2 |
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| Page | 203-211 |
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| Year/Month | 1992/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin (99mTc-GSA) is a new liver scintigraphy agent which binds to asialoglycoprotein receptor in hepatocyte. Studies were performed in three normal volunteers and 11 patients with liver cirrhosis. Time-activity curves for the heart and liver were obtained for 60 min following an i.v. injection of 99mTc-GSA (1 mg/185 MBq). We introduced five compart-ments to describe 99mTc-GSA: 1) extrahepatic blood, 2) hepatic blood, 3) receptor, 4) interstitial fluid and 5) urine. The %ID of 99mTc-GSA in blood and the hepatic blood volume were obtained from the extrapolation of the biexponential fitting for the heart and liver curves. Michaelis-Menten type saturation kinetics was applied to the process of receptor-ligand binding. Numerical analysis solved the simultaneous differential equa-tions that were introduced from the compartment model. Hepatic blood flow was 1,651 +- 131 ml/min, maximal removal rate for the ligand was 0.547 +- 0.069 mg/min in normal controls. Both results were significantly decreased in patients with liver cirrhosis compared with normal controls. Present study may provide a novel method for the diagnosis of liver function that allows independent quantifi-cation of the hepatic blood flow and the receptor population. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-galactosyl-human serum albumin, Compartment model, Hepatic blood flow, Asialoglycoprotein receptor, Liver cirrhosis. |
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