| Japanese |
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| Title | 99mTc-MIBIと99mTc-Teboroximeの心筋SPECT画像上の特徴 |
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| Subtitle | 原著 |
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| Authors | 久慈一英*, 中嶋憲一*, 滝淳一*, 谷口充*, 分校久志*, 利波紀久*, 久田欣一* |
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| Organization | *金沢大学医学部核医学教室 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 2 |
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| Page | 183-191 |
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| Year/Month | 1992/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-MIBI(N=8, 安静および負荷の16検査)と99mTc-Teboroxime(N=5)の心筋画像の特徴をSPECT像で201Tlと比較検討した. 99mTc-MIBIと201Tlの短軸像を用いて各壁の平均カウント濃度を得た. 下壁平均カウントの前壁平均カウントに対する比(I/A)は, 99mTc-MIBIが0.69±0.20で201Tlが0.62±0.16であり, 側壁平均カウントに対する比(I/L)は, それぞれ0.70±0.18と0.65±0.13であって, 99mTc-MIBIが201Tlより有意に高かった(p<0.05). 両比とも201Tlに対する比は, 1.11±0.17(I/A)と1.08±0.16(I/L)で99mTc-MIBIは下壁が約10%高かった. ファントム実験でも99mTcは201Tlよりも相対的に下壁が約15%高くなった. 99mTc-Teboroximeは, 3分ごとの経時的なdynamic SPECT短軸像に対して同様に前壁の平均カウントに対する各壁平均カウント濃度の比を得た. 約8分以降では肝臓集積が経時的に強まり正確な判定やBull's eye表示による定量上注意が必要なことがわかった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Tc-99m-MIBI, Tc-99m-Teboroxime, Tl-201, Myocardial scintigraphy, SPECT. |
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| English |
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| Title | Characteristics of the Myocardial SPECT Images of 99mTc-MIBI and 99mTc-Teboroxime |
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| Subtitle | Original Articles |
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| Authors | Ichiei KUJI, Kenichi NAKAJIMA, Junichi TAKI, Mitsuru TANIGUCHI, Hisashi BUNKO, Norihisa TONAMI, Kinichi HISADA |
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| Authors(kana) | |
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| Organization | Department of Nuclear Medicine, Kanazawa University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 2 |
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| Page | 183-191 |
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| Year/Month | 1992/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Characteristics of the myocardial distribution of 99mTc-MIBI and 99mTc-Teboroxime was compared with the myocardial distribution of 201Tl. We made summed myocardial images, in which central three short-axis SPECT slices were added. Rectangular region of interest (ROI) was set on each myocardial segment, and mean counts of each myocardial region was obtained using sum-med short-axis images. The ratio of inferior-to-anterior mean counts (I/A) was 0.69 +- 0.20 in 99mTc-MIBI and 0.62 +- 0.16 in 201Tl. The ratio of inferior-to-lateral mean counts was 0.70 +- 0.18 and 0.65 +- 0.13, respectively. Both ratios in 99mTc-MIBI were significantly higher than those in 201Tl (p<0.05). 201Tl to 99mTc-MIBI ratios of these two values were 1.11 +- 0.17 (I/A) and 1.08 +- 0.16 (I/L). The ratios of I/A and I/L of 99mTc-MIBI were about 10 percent higher than those of 201Tl. 99mTc-Teboroxime dynamic short-axis SPECT images of every three-minute were obtained. The ratios of counts in each wall were calculated simi-larly. After about 8 minutes, gradual increase in hepatic activity can be a cause of quantitative error in the assessment of SPECT images. We obtained the data with a human cardiac phantom. The myocardial phantom filled with 99mTc or 201Tl was placed in the mediastinal portion that is surrounded by the lung (saw dust) and vertebra (plastic bar). The ratio of I/A was 0.79 and I/L was 0.85 in 201Tl. The I/A ratio was 0.93 and I/L was 0.97 in 99mTc. Both ratios in 99mTc were about 15 percent higher than those in 201Tl. When we assess images quantitatively using these new 99mTc-labeled myocardial agents, it is necessary to interpret the images taking account of the characteristics, because the radiopharmaceutical distribution of these new agents are different from that of 201Tl. |
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| Practice | Clinical medicine |
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| Keywords | Tc-99m-MIBI, Tc-99m-Teboroxime, Tl-201, Myocardial scintigraphy, SPECT. |
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