| Japanese |
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| Title | 虚血性心疾患における123I-BMIPPシンチグラムの臨床的意義 - タリウム負荷心筋シンチグラム所見との比較検討 - |
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| Subtitle | 原著 |
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| Authors | 高尾祐治*, 村田啓*, 小宮山伸之**, 小野口昌久***, 大竹英二*, 丸野廣大* |
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| Organization | *虎の門病院放射線科, **循環器センター内科, ***放射線部 |
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| Journal | 核医学 |
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| Volume | 29 |
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| Number | 1 |
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| Page | 59-68 |
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| Year/Month | 1992/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」虚血性心疾患に対するヨード側鎖脂肪酸(BMIPP)の有用性を検討するため, 慢性期心筋梗塞症15例について安静時BMIPP scanと負荷タリウム(Tl)scanを行い, 比較した. Tlの4時間後再分布像とBMIPP像を比較すると60%以上の領域でBMIPPの異常の方が強く, むしろTl負荷直後像との一致率の方が高かった. 特にTlの不完全再分布領域や側副血行支配領域でその差は著しく, jeopardized areaの虚血を安静時BMIPP像で検出可能であることが示された. Tlで持続欠損か不完全再分布の領域はBMIPPで異常, Tlの正常領域はBMIPPでも正常だが, Tlで完全再分布の領域中BMIPPでも異常を認める割合は低値であり, BMIPPでの虚血検出の限界も示された. また, BMIPPで異常の領域には梗塞または虚血が存在し, 正常の領域には少なくとも梗塞は存在しないという判定も可能であった. 今回の結果から, BMIPPは虚血性心疾患における心筋代謝トレーサーとして有用であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | I-123-BMIPP, Thallium-201, Myocardial SPECT, Ischemic heart disease, Fatty acid metabolism. |
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| English |
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| Title | Evaluation of I-123-BMIPP Myocardial SPECT on the Detection of Ischemic Heart Disease by Comparing with Stress Thallium-201 Myocardial SPECT |
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| Subtitle | Original Articles |
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| Authors | Yuji TAKAO*, Hajime MURATA*, Nobuyuki KOMIYAMA**, Masahisa ONOGUCHI*, Eiji OHTAKE*, Hirotaka MARUNO* |
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| Authors(kana) | |
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| Organization | *Division of Nuclear Medicine, **Cardiovascular Center, Toranomon Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 29 |
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| Number | 1 |
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| Page | 59-68 |
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| Year/Month | 1992/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]To evaluate the usefulness of I-123-BMIPP as a tracer of fatty acid metabolism in ischemic heart disease, we performed both rest BMIPP myocardial SPECT and stress thallium-201 (Tl) SPECT in 15 patients with prior myocardial infarction, and compared the segmental findings each other. The abnormality of BMIPP images was more intense than that of Tl redistribution images (Tl-RD) in more than 60% of the abnormal segments. The degree of myocardial uptake of BMIPP was more concordant with that of Tl stress scan (Tl-EX) than with that of Tl-RD. This agreement of the findings between BMIPP and Tl-EX was found more remarkably in the regions of incomplete Tl redistribution or in the collateralized regions. These results revealed that ischemia in the jeopardized regions was able to be detected even by rest BMIPP scan. Abnormal findings in BMIPP were observed in more than 95% of segments with persistent defects or incomplete redistribution in Tl, but observed in only 41 or 45% of segments with complete redistribution. Normal findings in BMIPP were observed in 94% of normal segments in Tl. From these results, we can speculate that abnormal regions in BMIPP may have necrotic or ischemic myocardial tissue and normal regions in BMIPP may not have necrotic tissue. These results suggest that I-123-BMIPP may be available to detect myocardial ischemia or infarction in the clinical study. Additionally, the difference in findings between the early images and the delayed images in rest BMIPP scan was observed with relatively high incidence (14% of regions and 73% of patients). More detailed analysis will be required to reveal the importance of this difference. |
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| Practice | Clinical medicine |
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| Keywords | I-123-BMIPP, Thallium-201, Myocardial SPECT, Ischemic heart disease, Fatty acid metabolism. |
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