| Japanese |
|---|
| Title | 133Xe Functional Imageの経時的評価による線維化性肺疾患の病態解析 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 福田潔*, 長谷川鎮雄*, 武田徹**, 石川演美** |
|---|
| Authors(kana) | |
|---|
| Organization | *筑波大学臨床医学系呼吸器内科, **放射線科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 29 |
|---|
| Number | 1 |
|---|
| Page | 17-25 |
|---|
| Year/Month | 1992/1 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」非侵襲性, 非努力性で反復施行可能な133Xe Functional Imageによる半定量的局所肺機能分布解析を, 高齢者, 低肺機能症例の多い線維化性肺疾患症例に対して施行し, 従来からの胸部X線像, CT画像, 肺機能検査成績と比較検討した. 線維化性肺疾患は33例を対象とし, 正常例28例と比較し, 7症例については経時的変化についても検討を加えた. 線維化性肺疾患症例では, V・/VおよびQ・/Vともに両下肺野で指数の低下傾向がみられ, Q・/Vは両上肺野で指数の増加を示し, V・/Q・は全体的には上中下肺野間での指数差の減少傾向を示した. MWTは全肺平均が68±13秒と, 正常群の74±9秒に比べ短縮を示し, 上中肺野でも同様であった. 経時的変化では, V・/Vの変動は比較的少なく, Q・/Vは下肺野での血流低下の著名な進行傾向を認め, その結果V・/Q・はみかけ上全肺が均一化する結果となった. さらに, MWTは全例で経過とともに延長を示し, 本疾患の進行とともに, みかけ上の1秒率の低下がみられない局所的閉塞性障害が出現することが明らかとなり, 133Xe Functional Imageによる局所的機能障害分布解析の有用性が示された. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | 133Xe functional image, Fibrotic lung disease, Ventilation, Perfusion, Mean washout time. |
|---|
| English |
|---|
| Title | Analysis of Fibrotic Lung Diseases by Long-Term Evaluation with 133Xe Functional Imaging |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Kiyoshi FUKUDA*, Shizuo HASEGAWA*, Toru TAKEDA**, Nobuyoshi ISHIKAWA** |
|---|
| Authors(kana) | |
|---|
| Organization | *Respiratory Division, Department of Internal Medicine, University of Tsukuba, **Department of Radiology, University of Tsukuba |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 29 |
|---|
| Number | 1 |
|---|
| Page | 17-25 |
|---|
| Year/Month | 1992/1 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary]Semiquantitative analysis of regional lung function was carried out using 133Xe functional imaging, which can be performed repeatedly in a non-invasive and effortless way, on 33 patients with fibrotic lung disease, which often occurs in aged patients with decreased lung function. The results of this analysis were compared with those obtained by conventional methods, including chest X-ray and CT examinations and testing of whole lung function. The results obtained from the 33 patients (fibrotic group) were also compared with those obtained from 28 normal adults (control group), and 7 of the 33 patients were followed up for a long period of time. In the fibrotic group, both V・/V and Q・/V decreased in bilateral lower lung zones, while Q・/V increased in upper lung zones, resulting in a tendency toward less differences in V・/Q・ among upper, middle and lower zones. The mean MWT in the whole lung was shortened to 68 +- 13 sec. in the fibrotic group from 74 +- 9 sec. observed in the control group. Such a difference in MWT between the fibrotic and control groups was also seen in the upper and middle zones. As for long-term changes, although V・/V showed no marked changes, Q・/V demonstrated progressive and remarkable decreases in the lower lung zone, therefore, V・/Q・ was uniformly distributed over the whole lung in appearance. MWT was prolonged with time in all of the 7 patients. Thus it was clear that apparent regional obstructive dysfunction without decrease in FEV 1.0% emerged as fibrotic changes were worsened, and it was confirmed that analysis of regional lung function with 133Xe functional imaging is a very useful method of determining the state of fibrotic lung disease. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | 133Xe functional image, Fibrotic lung disease, Ventilation, Perfusion, Mean washout time. |
|---|