Japanese
Titleアデノシン三リン酸二ナトリウム (ATP) 負荷タリウムシンチグラフィの可能性と安全性に関する検討
Subtitle≪研究速報≫
Authors木下信一郎*, 山下三朗*, 鈴木哲男*, 村松俊裕*, 井出雅生*, 土肥豊*, 西村克之**, 宮前達也**
Authors(kana)
Organization*埼玉医科大学第二内科, **放射線科
Journal核医学
Volume28
Number12
Page1509-1513
Year/Month1991/12
Article報告
Publisher日本核医学会
Abstract「要旨」薬理作用持続時間のきわめて短いアデノシン三リン酸二ナトリウム(ATP)を用いた薬物負荷201Tlシンチグラフィの可能性と安全性につき検討した. 対象は虚血性心疾患患者8例である. ATPは体重1kg当たり1分間, 0.12mgを2例(A群)に, 0.16mgを3例(B群)に, 0.20mgを1例(C群)に, 0.28mgを2例(D群)に, 5分間持続注入した. 3分経過時点で201Tl111 MBq (3mCi)を静注した. 撮像は直後および3時間後に行った. A群では副作用はなかったが, 十分な血流差を誘発できなかった. B群では2例に胸痛が, 1例にST下降がみられた. 本群の201Tl像は冠動脈造影所見とよく一致した. C群では著しい血圧低下がみられた. D群の1例では完全房室ブロックが出現した. しかし, 全副作用出現例でいかなる治療も必要とせず, 症状, 所見は2分以内に軽減した. 虚血性心疾患診断のためにはATP 0.16mg/kg/分で5分間の持続静注法が安全かつ最適と考えられた.
Practice臨床医学：一般
KeywordsThallium-201, Adenosine triphosphate, Coronary artery disease, Emission computed tomography.
English
TitleThallium-201 Myocardial Scintigraphy after Intravenous Infusion of Adenosine Triphosphate Disodium : A Preliminary Study in the Diagnosis of Coronary Artery Disease
Subtitle
AuthorsShinichiro KINOSHITA*, Saburo YAMASHITA*, Tetsuo SUZUKI*, Toshihiro MURAMATSU*, Masao IDE*, Yutaka DOHI*, Katsuyuki NISHIMURA**, Tatsuya MIYAMAE**
Authors(kana)
Organization*Second Department of' Internal Medicine, Saitama Medical Sehool, **Department of Radiology, Saitama Medical School
JournalThe Japanese Journal of nuclear medicine
Volume28
Number12
Page1509-1513
Year/Month1991/12
ArticleReport
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] The feasibility and safety of thallium-201 myocardial scintigraphy after the intravenous infusion of adenosine triphosphate disodium (ATP) (Adetphos, Kowa) were studied in eight patients with angina pectoris and/or old myocardial infarction. Coronary arteriography (CAG) was performed by the conventional method in all patients. ATP was infused for 5 min and thallium was injected at 3 min after the start of ATP infusion. ATP was given at 0.12 mg/min/kg in two patients (group A), 0.16 mg/min/kg in three patients (group B), 0.20 mg/min/kg in one patient (group C) and 0.28 mg/min/kg in two patients (group D). SPECT images were obtained at 10 min and 180 min after thallium injection. No significant hemodynamic changes were observed in group A and B. Severe hypotension was observed in group C and one member of group D. Chest pain was experienced by one patient in group A, two in group B, one in group C, and both of the two in group D. ST depression on the electrocardiogram (ECG) was documented in one patient each of groups B and C. In one group D patient, the study was discontinued because of complete atrioventricular block persistent for 5 beats. The correlation between thallium imaging and CAG was unclear in group A, reasonable in groups B and C, and obscure in group D because of side effects. None of the patients who developed side effects of ATP were administered sublingual nitroglycerin or intravenous aminophylline. Their symptoms or ECG changes improved spontaneously within 2 min and disappeared within 5 min after termination of infusion. In conclusion, the optimal ATP regimen for this purpose was considered to be a 5 min infusion at 0.16 mg/kg/min and this method was found to be feasible and safe.
PracticeClinical medicine
KeywordsThallium-201, Adenosine triphosphate, Coronary artery disease, Emission computed tomography.

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