| Japanese |
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| Title | "Hot Spot" Imaging Agentsによる急性心筋梗塞の梗塞量の定量化 |
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| Subtitle | ≪原著≫ |
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| Authors | 吉田裕*, 望月守**, 坂田和之*, 武沢充**, 松本恭徳**, 吉村正己**, 森典子*, 横山正一*, 星野恒雄*, 鏑木恒男* |
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| Organization | *静岡県立総合病院循環器科, **核医学科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 12 |
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| Page | 1415-1422 |
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| Year/Month | 1991/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」急性心筋梗塞患者11例について111In抗ミオシン抗体(In-AMA)/201Tl (Tl)および99mTcピロリン酸(Tc-PYP)/Tl 2核種同時収集SPECTを施行し, In-AMAおよびTc-PYPの集積から梗塞量を求めた. cut-off levelはPYPが70%, In-AMAは80%とした. エネルギー設定およびウインドウ幅は, Tc-PYPが140keV±75%, Tlが75keV±10%, In-AMAは240keV±10%で, 収集時間はTc-PYP/Tlが1方向30秒, In-AMA/Tlが60秒とし32方向, 180°収集で行った. In-AMAは全例, Tc-PYPは10例で梗塞部位に一致したトレーサーの集積を認めた. この10例における梗塞量の平均はTc-PYPが32.5ml, In-AMAが21.9mlでTc-PYPがIn-AMAに比して有意に高値を示した. また両者の相関は, y=1.64x-3.58, r=0.98, p<0.001と良好であった. Tc-PYPから求めた梗塞量がIn-AMAから求めた梗塞量の約1.6倍であったのは, Tc-PYPが可逆的障害を受けた心筋細胞にも集積するためと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Indium-111 antimyosin antibody, Technetium-99m pyrophosphate, Acute myocardial infarction, Dual nuclide SPECT, Myocardial necrosis. |
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| English |
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| Title | Scintigraphic Quantification of Myocardial Necrosis Using "Hot Spot" Imaging Agents in Acute Myocardial Infarction |
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| Subtitle | - Original Articles - |
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| Authors | Hiroshi YOSHIDA*, Mamoru MOCHIZUKI**, Kazuyuki SAKATA*, Mitsuru TAKEZAWA**, Yasunori MATSUMOTO**, Masami YOSHIMURA**, Noriko MORI*, Shoichi YOKOYAMA*, Tsuneo HOSHINO*, Tsuneo KABURAGI* |
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| Authors(kana) | |
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| Organization | *Department Cardiology, **Department of Nuclear Medicine, Shizuoka General Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 12 |
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| Page | 1415-1422 |
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| Year/Month | 1991/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Both technetium-99m pyrophosphate/thallium-201 dual nuclide SPECT and indium-111 antimyosin antibody/thallium-201 dual nuclide SPECT were performed in identical 11 patients with acute myocardial infarction. Infarct size was calculated by both hot spot imaging agents on dual nuclide SPECT. Antimyosin accurately accumulated in the infarcted area in all 11 patients on SPECT images corresponding with the electrocardiography, but pyrophosphate accumulated at the site of infarct in 10 of 11 patients. The mean volume obtained from pyrophosphate was 32.5 ml and that from antimyosin was 21.9 ml. The relationship between infarct volume calculated by pyrophosphate and that by antimyosin was linear and correlated well (r=0.98, p<0.001). However the volume of infarction determined with pyrophosphate exceeded that with antimyosin SPECT by 1.64 (p<0.001). The reason for this difference is not yet known, but may relate to pyrophosphate uptake in border zones that may or may not be irreversibly injured. |
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| Practice | Clinical medicine |
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| Keywords | Indium-111 antimyosin antibody, Technetium-99m pyrophosphate, Acute myocardial infarction, Dual nuclide SPECT, Myocardial necrosis. |
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