| Japanese |
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| Title | ポジトロンCTによる肝細胞癌分化度評価の試み |
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| Subtitle | 研究速報 |
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| Authors | 榎本和夫*, 福長徹*, 岡住慎一*, 浅野武秀*, 菊池俊之*, 山本宏*, 長島通*, 磯野可一*, 伊藤裕**, 今関恵子***, 有水昇*** |
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| Organization | *千葉大学医学部第二外科, **放射線部, ***放射線科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 11 |
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| Page | 1353-1356 |
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| Year/Month | 1991/11 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」23例の肝細胞癌症例に対してFDGを用いたdynamic PETを行い, 非線型最小二乗法によりrate constants(K1〜K4)を求めた. 肝細胞癌のなかには, 画像上FDGが集積しない例があり, これらはK4/K3が高いことから, 集積の程度はK4の関与によると考えられた. 非癌部肝ではK3が低くK4/K3≧1.0の例が大部分を占めた. 肝細胞癌ではK3は非癌部肝よりも高かったが, FDGが集積しない例ではK3が比較的低くK4/K3が高い例が多いことから, K4/K3が肝細胞癌の機能的分化度の指標となり得ると考え, 予後との関係をみた. K4/K3とK3の値から3群に分けて, PETを行った時点からの生存率をみると, K4/K3≧0.4の群で生存率が最も良く, K3とK4によって肝細胞癌の分化度を推定できる可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | FDG, Positron emission tomography, Hepatocellular carcinoma, Functional differentiation. |
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| English |
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| Title | Can Fluorodeoxyglucose-Positron Emission Tomography Evaluate the Functional Differentiation of Hepatocellular Carcinoma? |
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| Authors | Kazuo ENOMOTO*, Tohru FUKUNAGA*, Shinichi OKAZUMI*, Takehide ASANO*, Toshiyuki KIKUCHI*, Hiroshi YAMAMOTO*, Tohru NAGASHIMA*, Kaichi ISONO*, Hiroshi ITOH**, Keiko IMAZEKI***, Noboru ARIMIZU*** |
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| Authors(kana) | |
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| Organization | *Second Department of Surgery, **Division of Radiology, ***Department of Radiology, Chiba University, School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 11 |
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| Page | 1353-1356 |
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| Year/Month | 1991/11 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Tumor uptake of 18F-fluorodeoxyglucose (FDG) was studied by dynamic positron emission tomog-raphy (PET) in 23 cases of hepatocellular carcinoma. The metabolic rate constants, K1 to K4, were generated by non-linear least square fitting method. We confirmed that K3 from the PET study significantly correlated with directly measured hexokinase activity of the cancer tissue. The region of HCC always had higher K3 values, which represents the hexokinase activity compared with the non-cancerous region. By FDG images, however, in 50% of cases the cancer region could not be clearly defined from the surrounding non-cancerous hepatic tissue. These HCC cases without accumulation of FDG had a high ratio of K4/K3 (K4 represents glucose-6-phosphatase activity), which correlated well with the inverse ratio of FDG accumulating images on PET. According to the PET images which is represented by K4/K3 and the hexokinase activity which is represented by K3, we divided these 23 cases into three groups and retrospectively compared their survival rates. The groups with high K4/K3 (>=0.40) had longer survival than other groups. From the view point of glucose metabolism, the value of K4/K3 cal-culated from dynamic studies of FDG-PET may represent the functional differentiation of HCC. |
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| Practice | Clinical medicine |
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| Keywords | FDG, Positron emission tomography, Hepatocellular carcinoma, Functional differentiation. |
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