| Japanese |
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| Title | In-111標識抗ミオシン抗体心筋シンチグラフィによる急性心筋梗塞の定量的評価の試み |
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| Subtitle | 原著 |
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| Authors | 成瀬均*, 森田雅人*, 板野緑子*, 山本寿郎*, 川本日出雄*, 福武尚重*, 大柳光正*, 岩崎忠昭*, 福地稔** |
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| Organization | *兵庫医科大学第一内科, **核医学科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 11 |
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| Page | 1273-1282 |
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| Year/Month | 1991/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」急性心筋梗塞の広がりを定量的に評価するため, 急性期にTl-201心筋シンチ(TL), ピロリン酸心筋シンチ(PYP)を行った心筋梗塞17例にIn-111標識抗ミオシンモノクローナル抗体心筋シンチグラフィ(InAM)を施行した. 梗塞量の算出法はPYPおよびInAMではvoxel counterを, TLではブルズアイ表示上でTL extent score, TL severity scoreを用いた. 心臓ファントムを用いた基礎実験より得られた最適cut-off値は65%から80%であった. voxel counterの臨床応用にはPYP:0.65, InAM:0.70のcut-off値を用いた. InAMとPYPにより算出した梗塞量を超音波断層心エコーによるwall motion abnormality index(WMAI), TL extent score, TL severity score, peak CK, ΣCKと比較した. その結果, InAMにより算出した梗塞量は他指標とそれぞれ, PYP:r=0.26(ns), TL extent score:r=0.72(p<0.01), TL severity score:r=0.65(p<0.05), WMAI:r=0.69(p<0.05)の相関関係であった. PYPによる梗塞量と各指標はいずれとも関係がなかった. 以上よりInAMによる梗塞量推定はPYPよりもTLの欠損, 壁運動異常部位と相関しており, 定量的評価法としてPYPよりも優れていると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Quantitative evaluation, Acute myocardial infarction, In-111 antimyosin Fab myocardial imaging, Cut-off level. |
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| English |
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| Title | Quantitative Evaluation of Acute Myocardial Infarction by In-111 Antimyosin Fab Myocardial Imaging |
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| Authors | Hitoshi NARUSE*, Masato MORITA*, Midoriko ITANO*, Juro YAMAMOTO*, Hideo KAWAMOTO*, Naoshige FUKUTAKE*, Mitsumasa OHYANAGI*, Tadaaki IWASAKI*, Minoru FUKUCHI** |
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| Authors(kana) | |
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| Organization | *First Department of Internal Medicine, **Department of Nuclear Medicine, Hyogo College of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 11 |
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| Page | 1273-1282 |
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| Year/Month | 1991/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Hyogo College of Medicine, Nishinomiya, Hyogo For quantitative evaluation of acute myocardial infarction, In-111 antimyosin Fab myocardial imaging (InAM) was performed in 17 patients with myocardial infarction who underwent Tl-201 (TL) and Tc-99m pyrophosphate (PYP) myocardial imaging in acute phase. For calculating the infarct size, voxel counter method was used for analysis in PYP and InAM, and extent and severity score were used on bull's-eye polar map in TL. The most appropriate cut-off level ranged from 65 to 80% by the fundamental experiment using cardiac phantom. The cut-off level of 0.70 (InAM) and 0.65 (PYP) were used for clinical application of voxel counter analysis. The infarct size calculated by InAM and PYP was compared with wall motion abnormality index by echocardiography (WMAI), TL extent score, TL severity score, peak CK and ICK. Infarct size by InAM showed the following correlations with other indices. PYP: r=0.26 (ns), TL extent score: r=0.72 (p<0.01), TL severity score: r=0.65 (p<0.05), WMAI: r=0.69 (p<0.05). The infarct size by PYP did not show any correlations with these indices. Therefore, the in-farct size by InAM showed better correlations with TL and WMAI than that of PYP. So InAM was considered superior to PYP for quantitative evaluation of acute myocardial infarction. |
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| Practice | Clinical medicine |
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| Keywords | Quantitative evaluation, Acute myocardial infarction, In-111 antimyosin Fab myocardial imaging, Cut-off level. |
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