| Japanese |
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| Title | Gliomaにおける201Tl塩化タリウムSPECTの有用性 |
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| Subtitle | 原著 |
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| Authors | 織内昇*, 田村勝**, 柴崎尚**, 井上登美夫*, 渡辺直行*, 舘野円*, 冨吉勝美*, 平野恒夫*, 五十嵐均***, 遠藤啓吾*, 佐々木康人**** |
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| Authors(kana) | |
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| Organization | *群馬大学医学部核医学科, **脳神経外科, ***附属病院中央放射線部, ****東京大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 11 |
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| Page | 1263-1271 |
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| Year/Month | 1991/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」腫瘍の悪性度と201Tlの集積程度との関係を明らかにすることを目的として, 201Tl SPECTを行った症例の腫瘍摘出術の際にbromodeoxyuridine(BUdR)を投与し, 得られた腫瘍組織を抗BUdRモノクローナル抗体で染色した. 染色された腫瘍細胞の割合をlabeling index(BUdR-LI)として腫瘍の悪性度の指標とし, 201Tlの集積程度の指標は, 病巣(D)とそれと対称な正常部(C)のカウント比をD/C ratio(%)として用いた. 14例のgliomaを対象に検討した結果, grade IまたはIIのBUdR-LIの平均は0.80±1.12であったのに対して, grade III, IVは, それぞれ5.17±3.32および7.67±3.77であった. 一方, 201TlのD/C ratioはそれぞれ94.2±11.9, 138.3±33.9, 198.7±31.7であった. またBUdR-LIとD/C ratioの間にはr=0.753の正の相関を認め, 細胞増殖の程度と201Tlの集積との相関が明らかにされた. 201Tl SPECTは, 増殖能を有する腫瘍組織の存在を正しく評価し, gliomaの非侵襲的な悪性度の判定, 治療後の効果や再発, および悪性化の判定に有用である. |
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| Practice | 臨床医学：一般 |
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| Keywords | Brain tumor, Glioma, 201Tl SPECT, BUdR, Cell kinetics. |
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| English |
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| Title | Evaluation of 201Tl SPECT in Patients with Glioma : A Comparative Study with Histological Diagnosis, Clinical Feature and Proliferative Activity |
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| Authors | Noboru ORIUCHI*, Masaru TAMURA**, Takashi SHIBAZAKI**, Tomio INOUE*, Naoyuki WATANABE*, Madoka TATENO*, Katsumi TOMIYOSHI*, Tsuneo HIRANO*, Hitoshi IGARASHI***, Keigo ENDO*, Yasuhito SASAKI**** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Neurosurgery, Gunma University School of Medicine, ***Department of Diagnostic Radiology, Gunma University Hospital, ****Department of Radiology, Faculty of Medicine, University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 11 |
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| Page | 1263-1271 |
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| Year/Month | 1991/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]The purpose of this study is to clarify the usefulness of 201Tl brain SPECT in the prediction of clinical degree of malignancy. Quantitative evaluation of 201Tl uptake in the tumor was expressed as count ratio of tumor site over contralateral normal region (D/C ratio) on 201Tl SPECT image. Fourteen patients with gliomas received an intravenous administration of bromodeoxyuridine (BUdR) at surgery to label tumor cells in the DNA synthesis phase. BUdR-positive cells in excised tumor specimen were stained with anti-BUdR monoclonal antibody by indirect immunoperoxydase staining. Percentage of labeled cells in relation to the total number of tumor cells in microscopic fields was defined as labeling index (BUdR-LI). D/C ratio in patients with grade IV glioma (198.7 +- 31.7) was higher than that in patients with grade III glioma (138.3 +- 33.9) or more low-grade gliomas (94.2 +- 11.9, p<0.001). BUdR-LI in patients with high-grade glioma was also higher than that in patients with low-grade glioma. D/C ratio correlated well (r=0.753) with BUdR-LI, which is considered to represent proliferative activity of the tumor. D/C ratio does not only correlate well with histological grade of glioma, but with clinical course or prognosis of individual patient with glioma. In conclusion, degree of 201Tl uptake in the tumor may provide non-invasive prediction of malignancy grade of gliomas and accurate estima-tion of efficacy of the therapy and early detection of recurrence or malignant transformation of the tumors, by delineating viable tumor tissue in patients with gliomas. |
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| Practice | Clinical medicine |
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| Keywords | Brain tumor, Glioma, 201Tl SPECT, BUdR, Cell kinetics. |
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