| Japanese |
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| Title | 99mTc-HMPAO標識白血球イメージングの炎症性疾患への応用 |
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| Subtitle | 原著 |
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| Authors | 油野民雄*, 滝淳一*, 絹谷清剛*, 秀毛範至*, 横山邦彦*, 高山輝彦*, 利波紀久*, 久田欣一*, 寺田一志** |
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| Organization | *金沢大学医学部核医学教室, **東邦大学大橋病院放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 10 |
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| Page | 1143-1150 |
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| Year/Month | 1991/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-HMPAO標識による白血球イメージングを炎症性疾患の評価に応用し, 基礎的検討をも加えながら臨床的有用性を検討した. 分離白血球と99mTc-HMPAOとのインキュベート終了直後の標識率は60.2±6.3%と, 従来の111In-oxine標識率に比べてかなり低い結果が得られたが, 標識白血球投与後の循環血液中に出現する割合(Recovery)やtrypan blue染色で標識された白血球の生物活性の変化度を評価した結果, 111In-oxine標識の場合と同程度の生物活性が保持された. 感染症15例を含む炎症性疾患疑い39例における67Gaイメージングとの対比では, 無病正診率の点で67Gaにはるかに優る結果が得られた. また急性感染症に絞った場合の有病正診率は78%と, 67Gaに比べて遜色のない成績を示した. 以上, 99mTc-HMPAO標識白血球イメージングは, 感染症(特に急性期)の評価法として有用であり, 111In-oxine標識白血球イメージングに代わりうる検査法と思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-white blood cell, 99mTc-HMPAO, Radionuclide inflammatory imaging. |
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| English |
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| Title | Clinical Application of Tc-99m HMPAO Labeled Leukocyte Imaging in Inflammatory Disease |
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| Subtitle | Original Articles |
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| Authors | Tamio ABURANO*, Junichi TAKI*, Seigo KINUYA*, Noriyuki SHUKE*, Kunihiko YOKOYAMA*, Teruhiko TAKAYAMA*, Norihisa TONAMI*, Kinichi HISADA*, Hitoshi TERADA** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, Kanazawa University Hospital, **Department of Radiology, Ohashi Hospital, Toho University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 10 |
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| Page | 1143-1150 |
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| Year/Month | 1991/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]A radionuclide imaging with Tc-99m HMPAO labeled leukocyte was performed in order to deter-mine its clinical usefulness in inflammatory disease. The mixed leukocyte isolated from 40 ml of whole blood containing 5 ml of acid citrate dextrose A and 7 ml of 6% hydroxyethyl starch was incubated with 370 MBq (10 mCi) of Tc-99m HMPAO at 37℃ for 30 minutes. Because the labeling efficiency of Tc-99m HMPAO labeled leukocyte was 60.2 +- 6.3%, the procedure of washing Tc-99m leukocyte with 5 ml of physiological saline was necessary before intravenous injection, in order to remove the unlabeled Tc-99m HMPAO. The recoveries of Tc-99m leukocyte in the blood after intravenous injection were 41.1 +- 6.7% at 5 minutes, 33.4 +- 2.1% at 30 minutes, and 27.2 +- 3.4% at 2 hours after injection. Moreover, the labeled leukocyte was not stained with trypan blue. Therefore, the biological activity of the Tc-99m leukocyte was maintained as that of In-111 oxine labeled leukocyte. In the 39 patients with clinical suspicion of inflammatory disease including 15 patients with acute and chronic infectious disease where both Tc-99m leukocyte and Ga-67 citrate imagings were performed, the sensitivity, specificity and accuracy for infectious disease were 47%, 100% and 79% with Tc-99m leukocyte, and 67%, 79% and 74% with Ga-67 citrate. These results suggest that Tc-99m HMPAO labeled leukocyte imaging is promising for evaluat-ing inflammatory disease because of the much higher specificity, the ready availability of Tc-99m HMPAO, the good image quality, and the lower radiation dose to the patient. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-white blood cell, 99mTc-HMPAO, Radionuclide inflammatory imaging. |
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