| Japanese |
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| Title | 99mTc-MIBIの第I相臨床試験 |
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| Subtitle | 原著 |
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| Authors | 久保敦司*, 中村佳代子*, 三宮敏和*, 清水正三*, 橋本省三*, 岩永史郎**, 半田俊之介**, 鳥塚莞爾*** |
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| Authors(kana) | |
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| Organization | *慶應義塾大学病院放射線科, **内科, ***福井医科大学学長 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 10 |
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| Page | 1133-1142 |
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| Year/Month | 1991/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」健常人ボランティア6名を対象に, 99mTc-MIBIの第I相臨床試験を実施した. 本剤投与後に軽度の一過性異常味覚が発現したが, 身体所見, 臨床検査値には本剤に起因すると思われる異常変動を認めず, 安全性の高い製剤であると考えられた. また, 本剤の吸収線量は, 最も高い大腸下部でも1.1mGy/37MBqであり, 十分許容範囲内であった. 本剤の血中消失は速やかであるが, 一方心筋への集積は投与後直ちに始まり, 安静時投与5分後で平均1.4%dose, 運動負荷時投与5分後では平均1.8%doseを示し, その後も心筋によく保持された. 心/肺比および心/肝比はともに良好であり, Planar像, SPECT像ともに高画質な心筋画像が得られた. 本剤は心筋血流シンチグラフィ製剤として有用と考えられた. 「I. はじめに」非侵襲的に心筋の血流状態を評価する核医学的方法としては, 塩化タリウム(201TlCl)を用いた心筋シンチグラフィが汎用されている. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-MIBI, Heart, Myocardial perfusion. |
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| English |
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| Title | Phase I Clinical Study on 99mTc-MIBI |
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| Subtitle | Original Articles |
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| Authors | Atsushi KUBO*, Kayoko NAKAMURA*, Toshikazu SANMIYA*, Shozo SHIMIZU*, Shozo HASHIMOTO*, Shiro IWANAGA**, Shunnosuke HANDA**, Kanji TORIZUKA*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Internal Medicine, Keio University Hospital, ***Fukui Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 10 |
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| Page | 1133-1142 |
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| Year/Month | 1991/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]A phase I clinical study on 99mTc-hexakis 2-methoxy isobutylisonitrile (99mTc-MIBI) was carried out in 6 normal volunteers. There was no significant change in vital signs and laboratory parameters attributing to the reagent other than complaint of slight and transient metallic taste immediately after the injection in 4 volunteers. The highest dosimetry was calculated as 1.1 mGy/37 MBq at lower large intestine, which was within the acceptable range. 99mTc-MIBI was rapidly cleared from the blood and accumulated in the heart immediately after the injection with 1.4% dose and 1.8% dose at 5 min at rest and at stress, respectively. The retention of radioactivity in the heart well continued for at least several hours. The heart-to-lung ratio was over 2.00 at 5 min and heart-to-liver ratio was over 1.00 at 60 min. Myocardial planar and SPECT images were obtained with high quality. In conclusion, 99mTc-MIBI is a useful myocardial perfusion imaging agent. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-MIBI, Heart, Myocardial perfusion. |
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