| Japanese |
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| Title | Tc-99m PYP, Tl-201, I-123 MIBG, In-111 AM心筋SPECT像が興味ある所見を示したPTCR成功例の一例 |
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| Subtitle | 症例報告 |
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| Authors | 田中健*, 相澤忠範*, 加藤和三*, 小笠原憲*, 桐ヶ谷肇*, 岡本淳* |
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| Organization | *心臓血管研究所 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 9 |
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| Page | 1099-1103 |
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| Year/Month | 1991/9 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」急性心筋梗塞に対して再灌流療法が成功し, 慢性期に壁運動が保たれている例のTc-99m pyrophosphate心筋像(PYP像), Tl-201心筋像(Tl像), I-123 Metaiodobenzylguanidine心筋像(MIBG像)やIn-111 antimyosin Fab心筋像(AM像)を得た. 第4病日のPYP像は, Tl像と前壁中隔で重なりを示した. 第24病日のTl像では, 第4病日に認めた取り込み低下所見の改善を認めた. 第48病日のMIBG像には, Tl-201心筋像の亜急性期異常部位に一致して欠損を認めた. 発生10か月後のAM像では, 壁運動を認める心尖部中隔に取り込みを認めた. これらの所見は, 亜急性期にまで続く持続性の虚血, 慢性期にも存在する除神経状態, また陳旧期にも存在する心筋細胞膜障害を示唆すると推定された. 再灌流療法により壊死から救われた心筋には, 正常心筋には認められない病態が存在し, その評価にRI心筋像はきわめて有用な役を果たすと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Tl-201 SPECT images, Tc-99m pyrophosphate, In-111 antimyosin Fab, I-123 Metaiodobenzylguanidine, Reperfusion therapy. |
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| English |
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| Title | Interesting PYP, Tl-201, MIBG and AM Myocardial SPECT Images in a Patient Under Successful Reperfusion Therapy |
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| Subtitle | |
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| Authors | Takeshi TANAKA, Tadanori AIZAWA, Kazuzo KATO, Ken OGASAWARA, Hajime KIRIGAYA, Kiyoshi OKAMOTO |
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| Authors(kana) | |
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| Organization | The Cardiovascular Institute |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 9 |
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| Page | 1099-1103 |
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| Year/Month | 1991/9 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Various types of radiopharmacons such as Tl-201, Tc-99m pyrophosphate (PYP), I-123 Metaiodobenzylguanidine (MIBG) and In-111 antimyosin Fab (AM), were applied to a patients under successful reperfusion therapy. In the patient QS waves in precordial leads and elevated serum enzyme activity was noted, however well anterior wall movement was maintained in chronic phase. At 4th hospital day PYP uptake was noted at apical region and basal anteroseptal region. Most portion of PYP uptake was overlapped by Tl-201 uptake. Depressed Tl-201 uptake in subacute phase improved. In chronic phase depressed MIBG uptake was noted at the region corresponding to the abnormal region in acute phase. Then months after the ischemic event AM uptake was noted at the region which maintained contractility. From these findings it was concluded as followings. Salvaged jeopardized myocardium remained ischemia in subacute phase. The lesions noted in the MIBG images showed depressed myocardial norepinephrine activity. This suggested that sympathetic nervous function was damaged by severe ischemia and the depressed sympathetic nervous function persisted long after myocardial perfusion had been restored. From abnormal AM uptake ten months after ischemic event it was suspected that myocardial cell membrane damage caused by severe ischemia might be persistent at the region which maintained contractility. Radioisotope image was useful to study pathological myocardium due to ischemic event. |
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| Practice | Clinical medicine |
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| Keywords | Tl-201 SPECT images, Tc-99m pyrophosphate, In-111 antimyosin Fab, I-123 Metaiodobenzylguanidine, Reperfusion therapy. |
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