| Japanese |
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| Title | 心筋梗塞症例における123I-BMIPPシンチグラフィの臨床的意義 |
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| Subtitle | 原著 |
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| Authors | 河本雅秀*, 玉木長良*, 米倉義晴*, 高橋範雄*, 小野晋司**, 野原隆司**, 神原啓文**, 河合忠一**, 伊藤秀臣***, 池窪勝治***, 加藤洋***, 小西淳二* |
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| Authors(kana) | |
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| Organization | *京都大学医学部核医学科, **第三内科, ***神戸市立中央市民病院 |
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| Journal | 核医学 |
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| Volume | 28 |
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| Number | 9 |
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| Page | 1081-1089 |
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| Year/Month | 1991/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」側鎖脂肪酸製剤である123I-BMIPPによる臨床治験を行った. 心筋梗塞27例にBMIPPシンチグラフィを施行し, 同時期に施行した201Tlシンチグラフィおよび左室造影所見と対比し, その意義を検討した. 安静時201Tlシンチグラフィで虚血を示した心筋区域100区域中34区域(34%)で, BMIPPの集積が201Tlに比し低下していた. この乖離は心筋梗塞発症後4週以内で75%, 4週以降で47%の症例に見られ, 発症早期の区域に高頻度であった(p<0.005). 虚血心筋のうちBMIPPと201Tlの間の乖離の見られる心筋は, 発症4週以降の症例では乖離の見られない心筋に比し壁運動は良好であった(おのおのスコア1.33と0.63, p<0.05). またこの乖離は201Tlの再分布現象の見られる心筋区域に多かった(82%)が, 再分布のない区域の一部(16%)でも乖離が見られた. したがって, BMIPPと201Tlの対比により, 心筋viabilityの評価が可能と考えられ, 201Tlの欠陥を補いうる方法である可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Emission computed tomography, 123I-BMIPP, Thallium-201, Fatty acid metabolism, Myocardial infarction. |
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| English |
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| Title | Value of Fatty Acid Imaging Using 123I-β-Methyl Iodophenyl Pentadecanoic Acid (BMIPP) to Assess Viability of Infarcted Myocardium |
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| Subtitle | Original Articles |
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| Authors | Masahide KAWAMOTO*, Nagara TAMAKI*, Yoshiharu YONEKURA*, Norio TAKAHASHI*, Shinji ONO**, Ryuji NOHARA**, Hirofumi KANBARA**, Chuichi KAWAI**, Hideomi ITO***, Katsuji IKEKUBO***, Hiroshi KATO***, Junji KONISHI* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **The Third Division, Department of Internal Medicine, Kyoto University Faculty of Medicine, ***Kobe General Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 28 |
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| Number | 9 |
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| Page | 1081-1089 |
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| Year/Month | 1991/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]To evaluate clinical value of a new fatty acid imaging tracer, 123I-β-methyl iodophenyl pentadecanoic acid (BMIPP), 27 patients with myo-cardial infarction (MI) underwent BMIPP imaging at rest. The results were compared with those of thallium-201 imaging and contrast ventriculography. Of 100 hypoperfused segments on thallium-201 imaging, 34 segments (34%) showed lower BMIPP uptake than thallium-201, and remaining 66 segments showed similar distribution of those tracers. This discrepancy was more often observed in a patients with acute or subacute stages of MI (<4 weeks from onset) than those with chronic stage of MI (>4 weeks)(75% vs. 47%; p<0.005). In addition, in the patients with chronic stage of MI, the regional wall motion abnormality was less severe in those showing discrepant BMIPP uptake than those showing concordant distribution (the wall motion score: 1.33 +- 0.62 vs. 0.63 +- 0.99; p<0.05). Furthermore, redistribution on stress thallium-201 imaging was more often observed in those showing discrepant BMIPP uptake (77%) than those showing concordant distribution (12%)(p<0.005). These preliminary study indicates that discrepant distribution of BMIPP and thallium-201 may be often observed, particularly in recent MI and those showing less wall motion abnormality and redistribution on stress thallium-201 imaging. Thus, the combined study of BMIPP and thallium-201 has a potential for assessing tissue viability in patients with MI. |
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| Practice | Clinical medicine |
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| Keywords | Emission computed tomography, 123I-BMIPP, Thallium-201, Fatty acid metabolism, Myocardial infarction. |
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